Pediatric acute myeloid leukemia with t(8;16)(p11;p13), a distinct clinical and biological entity: a collaborative study by the International-Berlin-Frankfurt-Munster AML-study group
| Autor: | Anne Auvrignon, John Swansbury, Valerie de Haas, Christine J. Harrison, Kiminori Terui, Henrik Hasle, Andrea Pession, Marta Jeison, Marry M. van den Heuvel-Eibrink, Barbara De Moerloose, Dirk Reinhardt, Vladimír Mihál, Daisuke Tomizawa, Mark Winstanley, Jeffrey E. Rubnitz, Eva A. Coenen, C. Michel Zwaan, Rob Pieters, Süreyya Savaşan, Todd A. Alonzo, Martin Zimmermann, Michael Dworzak, Donna L. Johnston, Oskar A. Haas, Vincent H.J. van der Velden, Kit Fai Wong, Goda Vaitkeviciene |
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| Přispěvatelé: | Pediatrics, Immunology, E. A. Coenen, C. M. Zwaan, D. Reinhardt, C. J. Harrison, O. A. Haa, V. de Haa, V. Mihal, B. De Moerloose, M. Jeison, J. E. Rubnitz, D. Tomizawa, D. Johnston, T. A. Alonzo, H. Hasle, A. Auvrignon, M. Dworzak, A. Pession, V. H. J. van der Velden, J. Swansbury, K.-f. Wong, K. Terui, S. Savasan, M. Winstanley, G. Vaitkeviciene, M. Zimmermann, R. Pieter, M. M. van den Heuvel-Eibrink |
| Rok vydání: | 2013 |
| Předmět: |
Oncology
Male medicine.medical_specialty congenital hereditary and neonatal diseases and abnormalities Myeloid Adolescent Immunology Remission Spontaneous P13) SPONTANEOUS REMISSION REARRANGEMENT CHILDHOOD Spontaneous remission Biology Biochemistry Translocation Genetic Internal medicine Germany hemic and lymphatic diseases medicine Humans ACUTE NONLYMPHOCYTIC LEUKEMIA ACUTE MONOBLASTIC LEUKEMIA ACUTE MYELOMONOCYTIC LEUKEMIA ACUTE MONOCYTIC LEUKEMIA HOX GENE-EXPRESSION TRANS-GOLGI NETWORK TRANSLOCATION T(8/16)(P11 Acute monocytic leukemia Cooperative Behavior Child neoplasms Myeloid Neoplasia Gene Expression Regulation Leukemic Infant Newborn Leukemia cutis Infant Cell Biology Hematology medicine.disease Prognosis Acute Monoblastic Leukemia Leukemia Leukemia Myeloid Acute medicine.anatomical_structure Child Preschool Acute myelomonocytic leukemia Cohort Female medicine.symptom Transcriptome Chromosomes Human Pair 16 Chromosomes Human Pair 8 |
| Zdroj: | Blood, 122(15), 2704-2713. American Society of Hematology Coenen, E A, Zwaan, C M, Reinhardt, D, Harrison, C J, Haas, O A, de Haas, V, Mihál, V, De Moerloose, B, Jeison, M, Rubnitz, J E, Tomizawa, D, Johnston, D, Alonzo, T A, Hasle, H, Auvrignon, A, Dworzak, M, Pession, A, van der Velden, V H J, Swansbury, J, Wong, K, Terui, K, Savasan, S, Winstanley, M, Vaitkeviciene, G, Zimmermann, M, Pieters, R & van den Heuvel-Eibrink, M M 2013, ' Pediatric acute myeloid leukemia with t(8;16)(p11;p13), a distinct clinical and biological entity : a collaborative study by the International-Berlin-Frankfurt-Munster AML-study group ', Blood, vol. 122, no. 15, pp. 2704-13 . https://doi.org/10.1182/blood-2013-02-485524 |
| ISSN: | 0006-4971 |
| DOI: | 10.1182/blood-2013-02-485524 |
| Popis: | In pediatric acute myeloid leukemia (AML), cytogenetic abnormalities are strong indicators of prognosis. Some recurrent cytogenetic abnormalities, such as t(8;16)(p11;p13),are so rare that collaborative studies are required to define their prognostic impact. We collected the clinical characteristics, morphology, and immunophenotypes of 62 pediatric AML patients with t(8; 16)(p11; p13) from 18 countries participating in the International Berlin-Frankfurt-Munster (I-BFM) AML study group. We used the AML-BFM cohort diagnosed from 1995-2005 (n = 543) as a reference cohort. Median age of the pediatric t(8; 16)(p11; p13) AML patients was significantly lower (1.2 years). The majority (97%) had M4-M5 French-American-British type, significantly different from the reference cohort. Erythrophagocytosis (70%), leukemia cutis (58%), and disseminated intravascular coagulation (39%) occurred frequently. Strikingly, spontaneous remissions occurred in 7 neonates with t(8; 16)(p11; p13), of whom 3 remain in continuous remission. The 5-year overall survival of patients diagnosed after 1993 was 59%, similar to the reference cohort (P = .14). Gene expression profiles of t(8; 16) (p11; p13) pediatric AML cases clustered close to, but distinct from, MLL-rearranged AML. Highly expressed genes included HOXA11, HOXA10, RET, PERP, and GGA2. In conclusion, pediatric t(8; 16)(p11; p13) AML is a rare entity defined by a unique gene expression signature and distinct clinical features in whom spontaneous remissions occur in a subset of neonatal cases. |
| Databáze: | OpenAIRE |
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