Age-dependent elevations in plasma kisspeptin are observed in boys and girls when compared with adults
| Autor: | Mohammad A. Ghatei, Nicola Bridges, Shakunthala Narayanaswamy, Waljit S. Dhillo, Channa N. Jayasena, Akila De Silva, Stephen R. Bloom, Gurjinder M. K. Nijher, Ali Abbara |
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| Rok vydání: | 2013 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Clinical Biochemistry Radioimmunoassay Puberty Precocious Neuropeptide Age dependent Adult women Kisspeptin Internal medicine medicine Humans Precocious puberty Blood test Child Kisspeptins medicine.diagnostic_test Plasma samples business.industry Reproduction Age Factors General Medicine medicine.disease Endocrinology Child Preschool Female business Biomarkers hormones hormone substitutes and hormone antagonists |
| Zdroj: | Annals of Clinical Biochemistry: International Journal of Laboratory Medicine. 51:89-96 |
| ISSN: | 1758-1001 0004-5632 |
| Popis: | Background Kisspeptin is a hypothalamic neuropeptide playing a physiological role in human reproduction. Genetic over-activation of kisspeptin causes precocious puberty in children. Concentrations of circulating kisspeptin are low in adults. The concentrations of plasma kisspeptin in boys and girls have not been studied previously. Methods Blood was obtained from 51 children and 63 adults. Plasma samples were analysed using radioimmunoassay. Children were aged 2–18 years, and attending hospital for a medically requested blood test unrelated to reproductive development. Data on pubertal status were not collected due to ethical reasons. Results Mean plasma kisspeptin was significantly higher in children when compared with adults (mean plasma kisspeptin in pmol/L: 12.3 ± 0.9, adults; 40.9 ± 3.3, children, P Conclusions We report that circulating kisspeptin is elevated in both boys and girls when compared with adults. Furthermore both boys and girls may have distinct, age-dependent concentrations of circulating kisspeptin. Further studies may determine if plasma kisspeptin could be used as a clinically useful biochemical marker of reproductive development in children. |
| Databáze: | OpenAIRE |
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