The oral retention and antiplaque efficacy of triclosan in human volunteers
| Autor: | R. J. Gilbert, P. E. O. Williams |
|---|---|
| Rok vydání: | 1987 |
| Předmět: |
Adult
Male Saliva business.product_category Dental Plaque Dental plaque Microbiology chemistry.chemical_compound Pharmacokinetics Dentifrice medicine Humans Pharmacology (medical) Antibacterial agent Pharmacology Chromatography Toothpaste Chemistry Phenyl Ethers Mouth Mucosa Half-life medicine.disease Triclosan business Toothpastes Half-Life Research Article |
| Zdroj: | British journal of clinical pharmacology. 23(5) |
| ISSN: | 0306-5251 |
| Popis: | An antiplaque toothpaste containing 0.2% (w/w) triclosan significantly inhibited overnight plaque growth in 12 human volunteers. After use of a 1 g quantity of the toothpaste containing 0.2% (w/w) [3H]-triclosan, 36.3 +/- 1.4% of the triclosan was retained. The mean concentration (+/- s.d.) achieved in saliva 5 min after toothpaste use was 8.16 +/- 2.50 micrograms g-1. The saliva decay curve for triclosan was consistent with a two phase model with t1/2 values of 0.45 h and 2.42 h, respectively. Triclosan was present in bacterial plaque for at least 8 h after dosage and in the oral mucosa for at least 3 h. |
| Databáze: | OpenAIRE |
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