Effects of taurine on plasma glucose concentration and active glucose transport in the small intestine

Autor:	Yo Tsuchiya, Koichi Kawamata
Rok vydání:	2017
Předmět:	Blood Glucose Male 0301 basic medicine Taurine medicine.medical_specialty Chloride Rats Sprague-Dawley Jejunum 03 medical and health sciences chemistry.chemical_compound Sodium-Glucose Transporter 1 0302 clinical medicine Chlorides Internal medicine Intestine Small medicine Animals 030212 general & internal medicine Rat Jejunum 030109 nutrition & dietetics digestive oral and skin physiology Glucose transporter Biological Transport General Medicine Plasma glucose concentration Small intestine Glucose Endocrinology medicine.anatomical_structure Intestinal Absorption Liver chemistry General Agricultural and Biological Sciences Cotransporter medicine.drug
Zdroj:	Animal Science Journal. 88:1763-1767
ISSN:	1344-3941
DOI:	10.1111/asj.12829
Popis:	Taurine lowers blood glucose levels and improves hyperglycemia. However, its effects on glucose transport in the small intestine have not been investigated. Here, we elucidated the effect of taurine on glucose absorption in the small intestine. In the oral glucose tolerance test, addition of 10 mmol/L taurine suppressed the increase in hepatic portal glucose concentrations. To investigate whether the suppressive effect of taurine occurs via down-regulation of active glucose transport in the small intestine, we performed an assay using the everted sac of the rat jejunum. Addition of taurine to the mucosal side of the jejunum suppressed active glucose transport via sodium-glucose cotransporter 1 (SGLT1). After elimination of chloride ions from the mucosal solution, taurine did not show suppressive effects on active glucose transport. These results suggest that taurine suppressed the increase in hepatic portal glucose concentrations via suppression of SGLT1 activity in the rat jejunum, depending on chloride ions.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7eb5360b87fb871c04086c7e209706f https://doi.org/10.1111/asj.12829 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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