Angiogenin and Osteoprotegerin are type II muscle specific myokines protecting pancreatic beta-cells against proinflammatory cytokines
| Autor: | Jakob S. Hansen, Michel Pinget, Bente Klarlund Pedersen, Cédric Howald, Peter Plomgaard, Emmanouil T. Dermitzakis, Sabine Rütti, Karim Bouzakri, Rodolphe Dusaulcy |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Angiogenin ddc:025.063/570 Muscle Fibers Skeletal Primary Cell Culture lcsh:Medicine Inflammation Biology Article Proinflammatory cytokine 03 medical and health sciences Insulin resistance ddc:590 Osteoprotegerin Internal medicine Insulin-Secreting Cells Myokine medicine Glucose homeostasis Homeostasis Humans ddc:576.5 ddc:612 Muscle Skeletal lcsh:Science Muscle Cells Multidisciplinary Myogenesis Tumor Necrosis Factor-alpha lcsh:R Ribonuclease Pancreatic medicine.disease 3. Good health 030104 developmental biology Endocrinology Diabetes Mellitus Type 2 Cytokines lcsh:Q medicine.symptom Insulin Resistance |
| Zdroj: | Scientific Reports, Vol 8, Iss 1, Pp 1-10 (2018) Rutti, S, Dusaulcy, R, Hansen, J S, Howald, C, Dermitzakis, E T, Pedersen, B K, Pinget, M, Plomgaard, P & Bouzakri, K 2018, ' Angiogenin and Osteoprotegerin are type II muscle specific myokines protecting pancreatic beta-cells against proinflammatory cytokines ', Scientific Reports, vol. 8, 10072 . https://doi.org/10.1038/s41598-018-28117-2 Scientific Reports Scientific Reports, Vol. 8, No 1 (2018) P. 10072 |
| ISSN: | 2045-2322 |
| Popis: | Tissue cross-talk is emerging as a determinant way to coordinate the different organs implicated in glucose homeostasis. Among the inter-organ communication factors, muscle-secreted myokines can modulate the function and survival of pancreatic beta-cells. Using primary human myotubes from soleus, vastus lateralis and triceps brachii muscles, we report here that the impact of myokines on beta-cells depends on fiber types and their metabolic status. We show that Type I and type II primary myotubes present specific mRNA and myokine signatures as well as a different sensitivity to TNF-alpha induced insulin resistance. Finally, we show that angiogenin and osteoprotegerin are triceps specific myokines with beta-cell protective actions against proinflammatory cytokines. These results suggest that type I and type II muscles could impact insulin secretion and beta-cell mass differentially in type 2 diabetes through specific myokines secretion. |
| Databáze: | OpenAIRE |
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