Antihypertensive properties of a traditional Chinese medicine GAO-ZI-YAO in elderly spontaneous hypertensive rats

Autor: Hui Zhang, Guo-Xing Zhang, Jing-Wei Chen, Zi-Zhang Wang, Meng-Xiao Han, Bin Dai
Rok vydání: 2020
Předmět:
Male
Vascular Endothelial Growth Factor A
0301 basic medicine
Nitric oxide (NO)
medicine.medical_specialty
Anti-Inflammatory Agents
Blood Pressure
Inflammation
RM1-950
Nitric Oxide
Angiotensin II (Ang II)
Nitric oxide
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Irbesartan
GAO-ZI-YAO
Rats
Inbred SHR
Internal medicine
medicine
Animals
Medicine
Chinese Traditional
Antihypertensive Agents
Pharmacology
Endothelin-1
business.industry
Angiotensin II
Interleukin
General Medicine
Rats
Vascular endothelial growth factor
030104 developmental biology
Blood pressure
Endocrinology
chemistry
030220 oncology & carcinogenesis
Hypertension
Cytokines
Tumor necrosis factor alpha
Therapeutics. Pharmacology
medicine.symptom
business
Spontaneous hypertensive rats (SHR)
Drugs
Chinese Herbal
medicine.drug
Zdroj: Biomedicine & Pharmacotherapy, Vol 131, Iss, Pp 110739-(2020)
ISSN: 0753-3322
DOI: 10.1016/j.biopha.2020.110739
Popis: Aim The present study aims to investigate the antihypertensive effect and the underlying mechanism of GAO-ZI-YAO, one of the traditional Chinese medicines, in elderly spontaneous hypertensive rats (SHR). Methods 12-month-old male SHRs were randomly divided into five groups on the basis of treatment with different doses of GAO-ZI-YAO or angiotensin II receptor-1 blocker (ARB, Irbesartan) for four weeks. Systolic blood pressure (SBP), and serum levels of nitric oxide (NO), endothelin-1 (ET-1), angiotensin II (Ang II), vascular endothelial growth factor (VEGF), interleukin (IL)-1β, IL-2, IL-6, and tumor necrotic factor (TNF)-α were measured. The pathological changes of ventricular muscle and thoracic aorta were observed by hematoxylin-eosin staining (H&E). Results GAO-ZI-YAO treatment reduced SBP in a dose-dependent manner accompanied by the inhibition of the development of cardiovascular remodeling. Although GAO-ZI-YAO treatment markedly increased serum levels of NO and suppressed serum levels of Ang II, this medicine did not affect the serum levels of ET-1 and VEGF. In addition, GAO-ZI-YAO also inhibited inflammatory response parameters (inflammatory cell infiltration in cardiac tissues and serum levels of IL-1β, IL-2, IL-6, and TNF-α) in a dose-dependent manner. Conclusion GAO-ZI-YAO exerts antihypertensive and anti-cardiovascular-remodeling effects in elderly SHR, which may be through regulation of NO, Ang II production, and inflammation.
Databáze: OpenAIRE
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