Effect of Perfluorohexane on the Expression of Cellular Adhesion Molecules and Surfactant Protein A in Human Mesothelial Cells In Vitro

Autor:	Matthias Hübler, Oliver Tiebel, Dirk Haufe, Klaus G Dahmen, Thea Koch
Rok vydání:	2011
Předmět:	Pathology medicine.medical_specialty genetic structures Cell Survival Biomedical Engineering Vascular Cell Adhesion Molecule-1 Lung injury Pharmacology chemistry.chemical_compound Materials Testing medicine Humans Viability assay Perfluorohexane Fluorocarbons Pulmonary Surfactant-Associated Protein A Chemistry Cell adhesion molecule Epithelial Cells Intercellular Adhesion Molecule-1 In vitro Surfactant protein A Gene Expression Regulation Tumor necrosis factor alpha Mesothelial Cell Biotechnology
Zdroj:	Artificial Cells, Blood Substitutes, and Biotechnology. 39:239-246
ISSN:	1532-4184 1073-1199
Popis:	The intraperitoneal instillation of perfluorocarbons augmented systemic oxygenation and was protective in mesenteric ischemia-reperfusion and experimental lung injury. To study biocompatibility and potential anti-inflammatory effects of intraperitoneal perfluorocarbons, we evaluated the influence of perfluorohexane and/or inflammatory stimuli on human mesothelial cells in vitro. Perfluorohexane exposure neither impaired cell viability nor induced cellular activation. TNFα enhanced ICAM-1 expression, which was not attenuated by simultaneous perfluorohexane treatment. Concentration of intracellular surfactant protein A tended to be higher in perfluorohexane treated cells compared to controls. Our in vitro data add further evidence that intraperitoneal perfluorocarbon application is feasible without adverse local effects.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7e772dbce418bc74d9b4b367a64e6e9 https://doi.org/10.3109/10731199.2010.550264 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
Nepřihlášeným uživatelům se plný text nezobrazuje	K zobrazení výsledku je třeba se přihlásit.