The gut microbiota in transplant patients
| Autor: | Pearlie P. Chong, Andrew Y. Koh |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Transplantation Conditioning
medicine.medical_treatment Colonisation resistance Gut flora digestive system Article 03 medical and health sciences 0302 clinical medicine immune system diseases medicine Humans biology business.industry Hematopoietic Stem Cell Transplantation Hematopoietic stem cell Immunosuppression Organ Transplantation Hematology Fecal bacteriotherapy Fecal Microbiota Transplantation medicine.disease biology.organism_classification Gastrointestinal Microbiome Transplantation surgical procedures operative medicine.anatomical_structure Oncology 030220 oncology & carcinogenesis Immunology Transplant patient business Dysbiosis 030215 immunology |
| Zdroj: | Blood Rev |
| ISSN: | 0268-960X |
| DOI: | 10.1016/j.blre.2019.100614 |
| Popis: | Solid organ transplant (SOT) and hematopoietic stem cell transplant (HSCT) recipients are at increased risk for developing infections due to underlying immunosuppression. Antibiotic use, and in HSCT recipients, the use of preparative regimens prior to transplantation can deplete gut commensal bacteria, resulting in intestinal dysbiosis. Emerging evidence in transplant patients, particularly HSCT, suggest that disturbances in gut microbiota populations are associated with a number of adverse outcomes. Here, we review the outcomes of HSCT and SOT recipients with gut microbiota imbalance or dysbiosis, explore the nascent field of gut microbiome therapeutic approaches including fecal microbiota transplantation and the use of precision probiotics in HSCT and SOT recipients. |
| Databáze: | OpenAIRE |
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