Associations between environmental factors and serological Epstein‐Barr virus antibodies in patients with nasopharyngeal carcinoma in South China

Autor: Wei Hua Jia, Ting Zhou, Wen Qiong Xue, Mei Qi Zheng, Yi Jing Jia, Yong Qiao He, Wen-Li Zhang, Ying Liao, Lei Lei Yuan, Da Wei Yang, Yi Xin Zeng
Jazyk: angličtina
Rok vydání: 2019
Předmět:
0301 basic medicine
Male
Cancer Research
Epstein-Barr Virus Infections
Herpesvirus 4
Human
cigarette smoking
medicine.disease_cause
Antibodies
Viral
Serology
0302 clinical medicine
herbal tea
Neutralizing antibody
Original Research
Aged
80 and over
Nasopharyngeal Carcinoma
biology
Middle Aged
lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Oncology
030220 oncology & carcinogenesis
Female
Antibody
Cancer Prevention
Adult
China
Adolescent
lcsh:RC254-282
Virus
03 medical and health sciences
Young Adult
Antigen
otorhinolaryngologic diseases
medicine
Humans
Radiology
Nuclear Medicine and imaging
Risk factor
Life Style
Aged
Neoplasm Staging
business.industry
Nasopharyngeal Neoplasms
medicine.disease
Epstein–Barr virus
Epstein‐Barr virus antibodies
stomatognathic diseases
030104 developmental biology
Nasopharyngeal carcinoma
Immunology
biology.protein
business
Teas
Herbal
Zdroj: Cancer Medicine
Cancer Medicine, Vol 8, Iss 10, Pp 4852-4866 (2019)
ISSN: 2045-7634
Popis: Epstein‐Barr virus (EBV) reactivation, reflected by aberrantly increased levels of various serological antibodies, has been suggested to be an early indicator of nasopharyngeal carcinoma (NPC) onset and progression. We have previously suggested that certain lifestyle and dietary factors were associated with elevated serological levels of the antibody against various EBV antigens namely VCA, Zta, EBNA1, and oral EBV DNA loads among healthy population. It remains unclear whether these potential environmental factors would also influence EBV serological antibodies in NPC patients. We conducted an epidemiological study to evaluate the associations between such environmental factors and EBV antibody levels among 1701 NPC patients in South China. Pretreatment serums were collected and examined for VCA‐IgA and EA‐IgA by immunoenzymatic assays and antienzyme rate (AER) of EBV DNase‐specific neutralizing antibody. We found that consumption of Canton‐style herbal tea was significantly correlated with increased serological antibody levels of VCA‐IgA and EA‐IgA, with adjusted ORs of 1.35 (95% CI: 1.03‐1.76) and 1.32 (95% CI: 1.01‐1.73), respectively, in the weekly intake frequency stratum, while not related to AER of EBV DNase‐specific neutralizing antibody. Smoking was found to be not only an apparent risk factor for higher antibody levels of AER in stage III‐IV patients (OR = 1.60, 95% CI: 1.11‐2.30), but also associated closely with NPC stage at diagnosis (OR = 2.17, 95% CI: 1.47‐3.22), with dose‐response effects. In conclusion, we found consumption of Canton‐style herbal tea and cigarette smoking were in positive associations with elevated EBV antibodies in NPC patients, which may be of public health significance for the primary prevention of EBV‐associated diseases especially NPC.
Databáze: OpenAIRE
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