Development of Clindamycin-Loaded Wound Dressing with Polyvinyl Alcohol and Sodium Alginate
| Autor: | Ma-Ro Hwang, Dong Xun Li, Sung Giu Jin, Jung Kil Park, Jun Young Choi, Han-Gon Choi, Chul Soon Yong, Won Seok Lyoo, Jong Oh Kim, Sun Woo Chang, Jeong Hoon Kim, Jung-Ae Kim, Jong Soo Woo |
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| Rok vydání: | 2008 |
| Předmět: |
Male
Alginates Surface Properties Pharmaceutical Science macromolecular substances complex mixtures Polyvinyl alcohol Absorption Excipients Rats Sprague-Dawley Wound care chemistry.chemical_compound Drug Stability Glucuronic Acid In vivo Tensile Strength Freezing Materials Testing Ultimate tensile strength Polymer chemistry medicine Animals Skin Pharmacology integumentary system Chemistry Clindamycin Hexuronic Acids technology industry and agriculture Proteins Hydrogels General Medicine Bandages Anti-Bacterial Agents Rats Cross-Linking Reagents Polyvinyl Alcohol Self-healing hydrogels Wounds and Injuries Swelling medicine.symptom Wound healing Protein adsorption Biomedical engineering |
| Zdroj: | Biological and Pharmaceutical Bulletin. 31:2277-2282 |
| ISSN: | 1347-5215 0918-6158 |
| DOI: | 10.1248/bpb.31.2277 |
| Popis: | To develop a clindamycin-loaded wound dressing, cross-linked hydrogel films were prepared using freeze-thawing method with various mixtures of polyvinyl alcohol (PVA) and sodium alginate (SA). The physicochemical properties such as swelling ratio, tensile strength and elongation of hydrogels were evaluated. The drug release from this clindamycin-loaded hydrogel, in vitro protein adsorption test and in vivo wound healing observations in rats were then performed. Increased SA concentration decreased the gelation %, maximum strength and break elongation, but it resulted into an increment in the swelling ability, elasticity and thermal stability of hydrogel film. However, SA had insignificant effect on the release of clindamycin. This hydrogel improved the healing rate of artificial wounds in rats. Thus, a clindamycin-loaded wound dressing with PVA and SA hydrogel should be a candidate for wound care. |
| Databáze: | OpenAIRE |
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