The performance of two automatic servo-ventilation devices in the treatment of central sleep apnea
| Autor: | James L. Goodwin, Mark G. Goetting, Paul Wylie, Sairam Parthasarathy, Rami Khayat, Shahrokh Javaheri |
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| Rok vydání: | 2011 |
| Předmět: |
Male
Central sleep apnea Respiratory rate medicine.medical_treatment Polysomnography law.invention Positive-Pressure Respiration Randomized controlled trial law Physiology (medical) medicine Humans Continuous positive airway pressure medicine.diagnostic_test Continuous Positive Airway Pressure business.industry Apnea Middle Aged medicine.disease Sleep Apnea Central respiratory tract diseases Exhalation Anesthesia Breathing Commentary Female Neurology (clinical) medicine.symptom business Hypopnea |
| Zdroj: | Sleep. 34(12) |
| ISSN: | 1550-9109 |
| Popis: | Introduction This study was conducted to evaluate the therapeutic performance of a new auto Servo Ventilation device (Philips Respironics autoSV Advanced) for the treatment of complex central sleep apnea (CompSA). The features of autoSV Advanced include an automatic expiratory pressure (EPAP) adjustment, an advanced algorithm for distinguishing open versus obstructed airway apnea, a modified auto backup rate which is proportional to subject's baseline breathing rate, and a variable inspiratory support. Our primary aim was to compare the performance of the advanced servo-ventilator (BiPAP autoSV Advanced) with conventional servo-ventilator (BiPAP autoSV) in treating central sleep apnea (CSA). Study design A prospective, multicenter, randomized, controlled trial. Setting Five sleep laboratories in the United States. Participants Thirty-seven participants were included. Measurements and results All subjects had full night polysomnography (PSG) followed by a second night continuous positive airway pressure (CPAP) titration. All had a central apnea index ≥ 5 per hour of sleep on CPAP. Subjects were randomly assigned to 2 full-night PSGs while treated with either the previously marketed autoSV, or the new autoSV Advanced device. The 2 randomized sleep studies were blindly scored centrally. Across the 4 nights (PSG, CPAP, autoSV, and autoSV Advanced), the mean ± 1 SD apnea hypopnea indices were 53 ± 23, 35 ± 20, 10 ± 10, and 6 ± 6, respectively; indices for CSA were 16 ± 19, 19 ± 18, 3 ± 4, and 0.6 ± 1. AutoSV Advanced was more effective than other modes in correcting sleep related breathing disorders. Conclusions BiPAP autoSV Advanced was more effective than conventional BiPAP autoSV in the treatment of sleep disordered breathing in patients with CSA. |
| Databáze: | OpenAIRE |
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