Salmeterol: a potent and long-acting inhibitor of inflammatory mediator release from human lung
| Autor: | C.J. Vardey, M. Johnson, P.R. Butchers |
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| Rok vydání: | 1991 |
| Předmět: |
Agonist
medicine.medical_specialty medicine.drug_class Propranolol In Vitro Techniques Histamine Release chemistry.chemical_compound Isoprenaline Internal medicine Hypersensitivity medicine Humans Albuterol Mast Cells Lung Salmeterol Xinafoate IC50 Inflammation Pharmacology Leukotriene C4 Prostaglandin D2 Adrenergic beta-Agonists respiratory system respiratory tract diseases Endocrinology chemistry SRS-A Salmeterol Histamine Research Article medicine.drug |
| Zdroj: | British Journal of Pharmacology. 104:672-676 |
| ISSN: | 0007-1188 |
| DOI: | 10.1111/j.1476-5381.1991.tb12487.x |
| Popis: | 1. The effects of salmeterol, a novel long-acting beta 2-adrenoceptor agonist, have been investigated on antigen-induced mediator release from passively sensitized fragments of human lung in vitro. 2. Salmeterol was a potent inhibitor of the release of histamine (-log IC50 = 8.54), leukotriene C4 (LTC4)/LTD4 (-log IC50 = 9.07) and prostaglandin D2 (-log IC50 = 8.81). It was slightly less potent (1-3 fold) than isoprenaline, but significantly more potent (10-35 fold) than salbutamol. 3. Propranolol competitively antagonized the inhibitory effects of salmeterol on histamine release (pA2 = 8.41) and LTC4/LTD4 release, (pA2 = 8.40) indicating an action via beta-adrenoceptors. 4. The inhibitory effects of isoprenaline (20 nM) and salbutamol (200 nM) were removed after washing the lung tissue for 2 h and 4 h respectively. In contrast, the inhibitory effects of salmeterol (40 nM) were much longer-lasting, and were still evident after 20 h. 5. Salmeterol therefore exhibits potent and persistent inhibition of anaphylactic mediator release from human lung. This anti-inflammatory effect may be important for the therapeutic potential of salmeterol in the treatment of bronchial asthma. |
| Databáze: | OpenAIRE |
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