Shedding of Rubella Virus among Infants with Congenital Rubella Syndrome Born in Tokyo, Japan, 2013-2014
| Autor: | Yukinao Hayashi, Naomi Seki, Michiya Hasegawa, Terue Okazaki, Tokuko Tsunoda, Konomi Murauchi, Yoshiyuki Sugishita, Yuuko Iwashita, Masayuki Kurita, Noriko Hayata, Aya Kayebeta, Masami Sumitomo, Tetsuya Akiba, Akemi Kai, Narumi Tahara |
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| Rok vydání: | 2015 |
| Předmět: |
0301 basic medicine
Microbiology (medical) Male Pediatrics medicine.medical_specialty Time Factors 030106 microbiology Rubella Syndrome Congenital medicine.disease_cause Rubella Polymerase Chain Reaction Congenital Rubella 03 medical and health sciences Pregnancy medicine Humans Prospective Studies Viral shedding Tokyo Congenital rubella syndrome business.industry Reverse Transcriptase Polymerase Chain Reaction Infant Newborn Outbreak Infant Rubella virus General Medicine medicine.disease Virus Shedding Rubella Infection Infectious Diseases Pharynx Female business |
| Zdroj: | Japanese journal of infectious diseases. 69(5) |
| ISSN: | 1884-2836 |
| Popis: | Rubella is usually a mild illness, with febrile rash being its main symptom. However, serious consequences of rubella infection can result when the infection occurs during the early stages of pregnancy. After the occurrence of a rubella outbreak in Japan that was observed from 2012 to 2013, 45 infants were reportedly born with congenital rubella syndrome (CRS). We prospectively followed the 15 CRS cases reported in Tokyo to determine the virus shedding periods by using nested reverse transcriptase-polymerase chain reaction to detect rubella virus genes. Throast swabs were used for virus detection. The virus shedding period was measured from birth until the time when the sample last tested positive followed by 2 consecutive negative samples. Kaplan-Meier method was used to estimate the proportion of cases remaining positive for rubella virus genes over time. The proportion of CRS cases shedding virus dropped steadily after birth, dropping to 33.8% at 6 months and 16.9% at 12 months. Our findings also suggested that the earlier the mother's onset of rubella during pregnancy, the longer the infant remained positive. Based on our findings, we believe that infants with CRS should be monitored for rubella virus shedding until 1 year of age. |
| Databáze: | OpenAIRE |
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