Estimation of influenza and respiratory syncytial virus hospitalizations using sentinel surveillance data—La Paz, Bolivia. 2012–2017

Autor:	Rakhee Palekar, Vicente Gonzales‐Armayo, Elvis Mendoza, Angel Veizaga, Rosario Rivera, Dabeyva Chavez, Arletta Añez, Claudia Salazar, Angel Rodriguez
Rok vydání:	2019
Předmět:	Adult Pulmonary and Respiratory Medicine Bolivia Surveillance data Adolescent Epidemiology respiratory syncytial virus Population Respiratory Syncytial Virus Infections 030312 virology Virus Young Adult 03 medical and health sciences Risk Factors Influenza Human Humans Medicine Respiratory system Child education Respiratory Tract Infections Aged Aged 80 and over Estimation 0303 health sciences education.field_of_study Indirect immunofluorescence business.industry Incidence Incidence (epidemiology) Public Health Environmental and Occupational Health Infant Original Articles Middle Aged Confidence interval Hospitalization Infectious Diseases Child Preschool SARI Original Article influenza business Sentinel Surveillance Demography
Zdroj:	Influenza and Other Respiratory Viruses
ISSN:	1750-2659 1750-2640
DOI:	10.1111/irv.12663
Popis:	Objective The objective was to estimate the number of hospitalizations associated with influenza and RSV using data from severe acute respiratory infection (SARI) sentinel surveillance from El Alto‐La Paz. Bolivia. Methods All persons who met the case definition for SARI at one sentinel hospital had a clinical sample collected and analyzed by rRT‐PCR for influenza and by indirect immunofluorescence for RSV. The SARI‐influenza and SARI‐RSV case counts were stratified by six age groups. The proportion of cases captured in the sentinel hospital in relation to the non‐sentinel hospitals of area was multiplied by the age‐specific census population, to build the denominators. The annual incidence and a 95% confidence interval (CI) were estimated. Results During 2012‐2017, n = 2606 SARI cases were reported (average incidence 120/100 000 inhabitants [95% CI: 116‐124]); the average incidence of influenza‐associated SARI hospitalization was 15.3/100 000 (95% CI: 14.1‐16.7), and the average incidence of RSV‐associated SARI hospitalization was 9/100 000 inhabitants (95% CI: 8.1‐10.1). The highest incidence of influenza was among those less than one year of age (average 174.7/100 000 [range: 89.1‐299.5]), followed by those one to four years of age (average 51.8/100 000 [range: 19.8‐115.4]) and then those 65 years of age and older (average 47.7/100 000 [range: 18.8‐117]). For RSV, the highest incidence was highest among those less than one year of age (231/100 000 [range: 119.9‐322.9]). Conclusion Influenza and RSV represent major causes of hospitalization in La Paz, Bolivia—with the highest burden among children under one year of age. Our estimates support current prevention strategies in this age group.
Databáze:	OpenAIRE
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