Inadequate cortisol response to the tetracosactide (Synacthen®) test in non-classic congenital adrenal hyperplasia: an exception to the rule?
| Autor: | Philippe Touraine, Isabelle Flechtner, Kathleen Laborde, Yves Morel, Christine Bellanné-Chantelot, Albane Simon, Jacques Beltrand, Caroline Thalassinos, Dinane Samara-Boustani, Marie Piketty, Graziella Pinto, Laura González-Briceño, Michel Polak, Athanasia Stoupa, Maud Bidet |
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| Rok vydání: | 2014 |
| Předmět: |
Male
medicine.medical_specialty Adolescent Endocrinology Diabetes and Metabolism Physiology Sensitivity and Specificity Endocrinology Cosyntropin Internal medicine medicine Adrenal insufficiency Adrenal function Humans Congenital adrenal hyperplasia Tetracosactide test Child Retrospective Studies Adrenal Hyperplasia Congenital business.industry Infant Retrospective cohort study medicine.disease Child Preschool Pediatrics Perinatology and Child Health Classic Congenital Adrenal Hyperplasia Female Pituitary-Adrenal Function Tests business hormones hormone substitutes and hormone antagonists |
| Zdroj: | Hormone research in paediatrics. 83(4) |
| ISSN: | 1663-2826 |
| Popis: | Aims: To describe cortisol response to tetracosactide and to review the literature on adrenal function in non-classic congenital adrenal hyperplasia (NCCAH) patients. Methods: We compared cortisol responses to tetracosactide (250 μg) between NCCAH patients and a comparison group (CG) of patients with premature pubarche and normal tetracosactide test. An adequate cortisol response was defined as a peak ≥18 μg/dl. Results: We included 35 NCCAH patients (26 girls, 9 boys), whose mean age at testing was 7.0 years (0.8-15.6), and 47 patients in the CG (39 girls, 8 boys), whose mean age was 7.2 years (0.5-9.9). Baseline cortisol was significantly higher in the NCCAH group than in the CG [12.9 (4.3-22.2) vs. 9.7 (4.2-16.2) μg/dl, respectively; p = 0.0006]. NCCAH patients had lower cortisol peak response compared to the CG [18.2 (6.3-40) vs. 24.9 (12-30.3) μg/dl, respectively; p < 0.0001]. Peak cortisol was Conclusions: The cortisol response to tetracosactide was inadequate ( |
| Databáze: | OpenAIRE |
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