The anti-inflammatory and immunosuppressive effects of glucocorticoids, recent developments and mechanistic insights
| Autor: | Karen E. Chapman, Agnes E. Coutinho |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Transcription
Genetic medicine.drug_class Anti-Inflammatory Agents Inflammation Review Biology Biochemistry Anti-inflammatory 03 medical and health sciences Glucocorticoid Receptors Glucocorticoid 0302 clinical medicine Insulin resistance Immune system Endocrinology 11-beta-Hydroxysteroid Dehydrogenase Type 1 Leukocytes medicine Animals Humans Clinical efficacy Glucocorticoids Molecular Biology 030304 developmental biology 0303 health sciences Type 2 Diabetes Mellitus Cell Differentiation 11β-Hydroxysteroid dehydrogenase medicine.disease 3. Good health Gene Expression Regulation Immune System Metabolic effects Immunology medicine.symptom Immunosuppressive Agents 030217 neurology & neurosurgery Signal Transduction medicine.drug |
| Zdroj: | Molecular and Cellular Endocrinology Coutinho, A E & Chapman, K E 2011, ' The anti-inflammatory and immunosuppressive effects of glucocorticoids, recent developments and mechanistic insights ', Molecular and Cellular Endocrinology, vol. 335, no. 1, pp. 2-13 . https://doi.org/10.1016/j.mce.2010.04.005 |
| ISSN: | 0303-7207 |
| DOI: | 10.1016/j.mce.2010.04.005 |
| Popis: | Since the discovery of glucocorticoids in the 1940s and the recognition of their anti-inflammatory effects, they have been amongst the most widely used and effective treatments to control inflammatory and autoimmune diseases. However, their clinical efficacy is compromised by the metabolic effects of long-term treatment, which include osteoporosis, hypertension, dyslipidaemia and insulin resistance/type 2 diabetes mellitus. In recent years, a great deal of effort has been invested in identifying compounds that separate the beneficial anti-inflammatory effects from the adverse metabolic effects of glucocorticoids, with limited effect. It is clear that for these efforts to be effective, a greater understanding is required of the mechanisms by which glucocorticoids exert their anti-inflammatory and immunosuppressive actions. Recent research is shedding new light on some of these mechanisms and has produced some surprising new findings. Some of these recent developments are reviewed here. |
| Databáze: | OpenAIRE |
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