A dosimetric comparison of the Contura multilumen balloon breast brachytherapy catheter vs. the single-lumen MammoSite balloon device in patients treated with accelerated partial breast irradiation at a single institution
| Autor: | Kenneth Haile, Philip Z. Israel, Doyle Keith Pope, Sheree Brown, Mark McLaughlin, Lorie Hughes, Maureen Lyden |
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| Rok vydání: | 2009 |
| Předmět: |
Catheters
business.industry Brachytherapy Planning target volume Partial Breast Irradiation Breast Neoplasms Radiotherapy Dosage Balloon medicine.disease Catheter Breast cancer Oncology medicine Humans Radiology Nuclear Medicine and imaging In patient Female Single institution Nuclear medicine business Radiation Injuries Breast brachytherapy Skin |
| Zdroj: | Brachytherapy. 10(1) |
| ISSN: | 1873-1449 |
| Popis: | A comparison of dosimetric findings in 33 patients treated with the Contura multilumen balloon (SenoRx Inc., Irvine, CA) (C-MLB) breast brachytherapy catheter vs. 33 patients treated with the MammoSite (Hologic Inc., Bedford, MA) (MS) at a single institution to deliver accelerated partial breast irradiation (APBI) was performed.CT-based 3-dimensional planning with dose optimization was completed. APBI treatment of 34Gy in 3.4Gy fractions was delivered. Endpoints analyzed included: (1) The percentage of the prescribed dose (PD) covering the planning target volume (PTV), (2) the maximum skin dose as a percentage of the PD, (3) the maximum rib dose as a percentage of the PD, and (4) the V150 and V200.The C-MLB was placed more frequently in patients with closer skin spacing (7mm) and rib spacing (7mm) than in MS patients (45.5% vs. 12.1%, p=0.0057 and 57.6 vs. 33.3, p=0.0131, respectively). Despite closer skin spacing, the overall median skin dose was significantly lower in C-MLB patients (112% of the PD vs. 134%, p=0.0282). No statistically significant differences in the V150 or V200 were observed. In patients with very limited rib spacing (4mm), the C-MLB delivered significantly lower rib doses than the MS (144% of the PD vs. 191%, p=0.0107). In all clinical scenarios, coverage of the PTV with the C-MLB was either equal to or significantly better than with the MS (p=0.0024).The C-MLB catheter produced clinically significant improvements in dosimetric endpoints (e.g., reduced skin and rib doses and improved PTV coverage) in most clinical scenarios. |
| Databáze: | OpenAIRE |
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