The impact of early immune destruction on the kinetics of postacute viral replication in rhesus monkey infected with the simian-human immunodeficiency virus 89.6P
| Autor: | Xiaoping Liang, Anthony Carella, John W. Shiver, Brett Connolly, Charles Tan, Danilo R. Casimiro, Emilio A. Emini, Hilton J. Klein, Larry Handt, Aimin Tang, Minchun Chen, William A. Schleif, Michael McElhaugh, Tong-Ming Fu, Mary-Ellen Davies, Susan Hill, Keith A. Wilson, Zhiqiang Zhang |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
CD4-Positive T-Lymphocytes
Time Factors animal diseases viruses Simian Acquired Immunodeficiency Syndrome Viremia Biology Virus Replication Immune system Immunity Viral entry Virology Viral replication medicine Animals Lymph node Recombination Genetic B-Lymphocytes Germinal center Germinal Center medicine.disease Macaca mulatta CD4 Lymphocyte Count SHIV 89.6P Disease Models Animal medicine.anatomical_structure Acute Disease Immunology HIV-1 Rhesus monkey RNA Viral Simian Immunodeficiency Virus Lymph Nodes Viral load |
| Zdroj: | Virology. 320(1):75-84 |
| ISSN: | 0042-6822 |
| DOI: | 10.1016/j.virol.2003.11.017 |
| Popis: | Set-point viral load is positively correlated with the extent of initial viral replication in pathogenic simian-human immunodeficiency virus (SHIV) infection. To elucidate the mechanisms underlying the correlation, we conducted a systematic investigation in rhesus monkeys infected with the highly pathogenic SHIV 89.6P. This model is widely used in the preclinical evaluation of AIDS vaccine candidates and a thorough understanding of the model's biology is important to the proper interpretation of these evaluations. We found that the levels of peak viremia were positively correlated not only with the levels of set-point viremia but, importantly, with the extent of initial overall immune destruction as indicated by the degree of CD4+ T cell depletion and lymph node germinal center (GC) formation. The extent of initial overall immune destruction was inversely correlated with subsequent development and maintenance of virus-specific cellular and humoral immune responses. Thus, these data suggest that the extent of early immune damage determines the development and durability of virus-specific immunity, thereby playing a critical role in establishing the levels of set-point viral replication in SHIV infection. Vaccines that limit both the initial viral replication and the extent of early immune damage will therefore mediate long-term virus replication control and mitigation of long-term immune destruction in this model of immunodeficiency virus infection. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect