Accuracy of cystatin C for the detection of abnormal renal function in children undergoing chemotherapy for malignancy: a systematic review using individual patient data
| Autor: | Whiting, Penny, Birnie, Kate, Sterne, Jonathan, Jameson, Catherine, Skinner, Rod, Phillips, Bob, Barnfield, Mark, Blufpand, Hester, Bokenkamp, Arend, Grönroos, Marika, Lankisch, Petra, Philips, Bob |
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| Rok vydání: | 2017 |
| Předmět: |
Male
medicine.medical_specialty Adolescent Urology Renal function urologic and male genital diseases Malignancy Logistic regression Diagnostic accuracy Nephrotoxicity 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Neoplasms Humans Chemotherapy Medicine Renal Insufficiency 030212 general & internal medicine Cystatin C Child Children Qualitative Research reproductive and urinary physiology Creatinine biology business.industry Cancer Middle Aged medicine.disease female genital diseases and pregnancy complications Oncology chemistry 030220 oncology & carcinogenesis Systematic review biology.protein Female Cystatin business |
| Zdroj: | Whiting, P, Birnie, K, Sterne, J, Jameson, C, Skinner, R, Phillips, B, Barnfield, M, Blufpand, H, Bokenkamp, A, Grönroos, M, Jameson, C, Lankisch, P, Philips, B, Skinner, R, Sterne, J, Whiting, P 2017, ' Accuracy of cystatin C for the detection of abnormal renal function in children undergoing chemotherapy for malignancy : a systematic review using individual patient data ', Supportive Care in Cancer, pp. 1-10 . https://doi.org/10.1007/s00520-017-4002-3 |
| ISSN: | 1433-7339 0941-4355 |
| Popis: | We conducted a systematic review and individual patient data (IPD) meta-analysis to examine the utility of cystatin C for evaluation of glomerular function in children with cancer. Eligible studies evaluated the accuracy of cystatin C for detecting poor renal function in children undergoing chemotherapy. Study quality was assessed using QUADAS-2. Authors of four studies shared IPD. We calculated the correlation between log cystatin C and GFR stratified by study and measure of cystatin C. We dichotomized the reference standard at GFR 80 ml/min/1.73m2 and stratified cystatin C at 1 mg/l, to calculate sensitivity and specificity in each study and according to age group (0–4, 5–12, and ≥ 13 years). In sensitivity analyses, we investigated different GFR and cystatin C cut points. We used logistic regression to estimate the association of impaired renal function with log cystatin C and quantified diagnostic accuracy using the area under the ROC curve (AUC). Six studies, which used different test and reference standard thresholds, suggested that cystatin C has the potential to monitor renal function in children undergoing chemotherapy for malignancy. IPD data (504 samples, 209 children) showed that cystatin C has poor sensitivity (63%) and moderate specificity (89%), although use of a GFR cut point of |
| Databáze: | OpenAIRE |
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