Metabolic syndrome definitions and components in predicting major adverse cardiovascular events after kidney transplantation
| Autor: | Jeffrey S. Zaltzman, Lindita Rapi, Samuel A. Silver, Michael Huang, Ali I. Al-Lawati, G. V. Ramesh Prasad, Michelle M. Nash |
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| Rok vydání: | 2014 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Kaplan-Meier Estimate Cohort Studies Diabetes Complications Young Adult Predictive Value of Tests Risk Factors Internal medicine medicine Humans Obesity Prospective Studies cardiovascular diseases Aged Dyslipidemias Proportional Hazards Models Retrospective Studies Metabolic Syndrome Transplantation Framingham Risk Score business.industry Proportional hazards model Hazard ratio Middle Aged medicine.disease Kidney Transplantation Surgery Treatment Outcome Cardiovascular Diseases Cardiology Kidney Failure Chronic Female Microalbuminuria Metabolic syndrome business Dyslipidemia Mace |
| Zdroj: | Transplant International. 28:79-88 |
| ISSN: | 0934-0874 |
| DOI: | 10.1111/tri.12450 |
| Popis: | Summary Metabolic syndrome (MetS) associates with cardiovascular risk post-kidney transplantation, but its ambiguity impairs understanding of its diagnostic utility relative to components. We compared five MetS definitions and the predictive value of constituent components of significant definitions for major adverse cardiovascular events (MACE) in a cohort of 1182 kidney transplant recipients. MetS definitions were adjusted for noncomponent traditional Framingham risk factors and relevant transplant-related variables. Kaplan–Meier, logistic regression, and Cox proportional hazards analysis were utilized. There were 143 MACE over 7447 patient-years of follow-up. Only the World Health Organization (WHO) 1998 definition predicted MACE (25.3 vs 15.5 events/1000 patient-years, P = 0.019). Time-to-MACE was 5.5 ± 3.5 years with MetS and 6.8 ± 3.9 years without MetS (P |
| Databáze: | OpenAIRE |
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