Proinflammatory cytokines and elastase-alpha-1-antitrypsin in Argentine hemorrhagic fever
| Autor: | Felisa C. Molinas, Julio I. Maiztegui, R F Marta, C. E. Hack, A. Sturk, V.S. Montero |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
medicine.medical_treatment
Argentine hemorrhagic fever Hemorrhagic Fever American Proinflammatory cytokine Virology Medicine Humans Interleukin 6 biology business.industry Interleukin-6 Tumor Necrosis Factor-alpha Elastase Interleukin-8 medicine.disease biology.organism_classification Receptors Interleukin-6 Pathophysiology Interleukin-10 Infectious Diseases Cytokine Junin virus alpha 1-Antitrypsin Immunology biology.protein Cytokines Parasitology Tumor necrosis factor alpha business Leukocyte Elastase |
| Zdroj: | The American journal of tropical medicine and hygiene. 60(1) |
| ISSN: | 0002-9637 |
| Popis: | Argentine hemorrhagic fever (AHF) is a disease caused by Junin virus. In the acute phase, patients present hematologic and neurologic involvement with high levels of interferon-alpha and tumor necrosis factor-alpha (TNF-alpha. Nineteen patients with a confirmed diagnosis of AHF were studied: six severe, four moderate and nine mild cases. Serum levels of interleukin-6 (IL-6), IL-6 soluble receptor (IL-6sR), IL-8, IL-10, and elastase-alpha1-antitrypsin complex (E-alpha 1AT) were assayed by ELISAs. Levels of IL-6, IL-8, and IL-10 were high in nine, 12, and 13 patients, respectively, while levels of IL-6sR were high in two patients and low in one patient. Seven patients had increased levels of E-alpha1AT. Significant correlations were found between levels of both IL-8 and IL-10 with those of TNF-alpha as well as between IL-8 and E-alpha 1AT. These data demonstrate activation of pro-inflammatory and anti-inflammatory cytokine pathways, and statistical analysis showed differences among the clinical forms of illness. This study shows that IL-8 plays an essential role in neutrophil activation in AHF patients as demonstrated in other infectious diseases. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|