Active Nano-targeting of Macrophages
| Autor: | Natasa Gaspar, Laura Mezzanotte, Clemens M.W.G. Löwik, Giorgia Zambito |
|---|---|
| Přispěvatelé: | Molecular Genetics, Radiology & Nuclear Medicine |
| Rok vydání: | 2019 |
| Předmět: |
Pharmacology
0303 health sciences Macrophages Macrophage polarization Cancer 02 engineering and technology Disease Biology 021001 nanoscience & nanotechnology medicine.disease 03 medical and health sciences Drug Delivery Systems Drug Discovery medicine Cancer research Humans Nanoparticles Nanotechnology Macrophage Macrophage depletion Tissue distribution 0210 nano-technology 030304 developmental biology |
| Zdroj: | Current Pharmaceutical Design, 25(17), 1951-1961. Bentham Science Publishers B.V. |
| ISSN: | 1381-6128 |
| Popis: | Macrophages play a role in almost every disease such as cancer, infections, injuries, metabolic and inflammatory diseases and are becoming an attractive therapeutic target. However, understanding macrophage diversity, tissue distribution and plasticity will help in defining precise targeting strategies and effective therapies. Active targeting of macrophages using nanoparticles for therapeutic purposes is still at its infancy but holds promises since macrophages have shown high specific uptake of nanoparticles. Here we highlight recent progress in active nanotechnology-based systems gaining pivotal roles to target diverse macrophage subsets in diseased tissues. |
| Databáze: | OpenAIRE |
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