Sterol uptake by the NPC system in eukaryotes: a Saccharomyces cerevisiae perspective
| Autor: | Mikael B. L. Winkler, Lynette Nel, Kelly M. Frain, Emil Dedic, Esben Olesen, Bjørn Panyella Pedersen |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
0303 health sciences
Biophysics Cell Biology Saccharomyces cerevisiae Biochemistry 03 medical and health sciences 0302 clinical medicine Structural Biology Genetics polycyclic compounds lipids (amino acids peptides and proteins) Molecular Biology 030217 neurology & neurosurgery 030304 developmental biology |
| Zdroj: | Winkler, M B L, Nel, L, Frain, K M, Dedic, E, Olesen, E & Pedersen, B P 2022, ' Sterol uptake by the NPC system in eukaryotes : a Saccharomyces cerevisiae perspective ', FEBS Letters, vol. 596, no. 2, pp. 160-179 . https://doi.org/10.1002/1873-3468.14253 |
| ISSN: | 1873-3468 |
| DOI: | 10.1002/1873-3468.14253 |
| Popis: | Sterols are an essential component of membranes in all eukaryotic cells and the precursor of multiple indispensable cellular metabolites. After endocytotic uptake, sterols are integrated into the lysosomal membrane by the Niemann-Pick type C (NPC) system before redistribution to other membranes. The process is driven by two proteins that, together, compose the NPC system: the lysosomal sterol shuttle protein NPC2 and the membrane protein NPC1 (named NCR1 in fungi), which integrates sterols into the lysosomal membrane. The Saccharomyces cerevisiae NPC system provides a compelling model to study the molecular mechanism of sterol integration into membranes and sterol homeostasis. This review summarizes recent advances in the field, and by interpreting available structural data, we propose a unifying conceptual model for sterol loading, transfer and transport by NPC proteins. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text