(R)-Sila-venlafaxine: A selective noradrenaline reuptake inhibitor for the treatment of emesis

Autor:	Julie B. H. Warneck, Graham A. Showell, Reinhold Tacke, Matthew J. Barnes, John Gary Montana, Juergen Daiss, John S. Mills
Rok vydání:	2006
Předmět:	Male Models Molecular Drug Tertiary amine Vomiting medicine.drug_class Stereochemistry media_common.quotation_subject Sila-Venlafaxine Clinical Biochemistry Drug Evaluation Preclinical Pharmaceutical Science Venlafaxine Noradrenaline reuptake inhibitor In Vitro Techniques Pharmacology Crystallography X-Ray Biochemistry Structure-Activity Relationship Norepinephrine Drug Discovery medicine Animals Humans Serotonin 5-HT3 Receptor Antagonists Antiemetic Molecular Biology media_common Molecular Structure Chemistry Organic Chemistry Ferrets Venlafaxine Hydrochloride Stereoisomerism Biological activity General Medicine Serotonin reuptake Cyclohexanols Disease Models Animal Antiemetics Molecular Medicine Antidepressant Reuptake inhibitor Selective Serotonin Reuptake Inhibitors medicine.drug
Zdroj:	Bioorganic & Medicinal Chemistry Letters. 16:2555-2558
ISSN:	0960-894X
Popis:	Sila-substitution of drugs (the carbon/silicon switch) is a concept that is being successfully used for the development of new chemical entities. The (R)-sila-analogue of the antidepressant venlafaxine is devoid of the serotonin reuptake inhibition observed with the marketed drug, leading to a selective noradrenaline reuptake inhibitor displaying anti-emetic properties.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7d5270a4cb60680fed2be2f62412efe https://doi.org/10.1016/j.bmcl.2005.12.062 Zobrazit plný text záznamu Full Text from ScienceDirect