Immune-complex inhibition of lymphocyte Fc gamma-receptors in primary biliary cirrhosis: a possible immunomodulatory mechanism
| Autor: | P.R. Mills, I. Galbraith, G.P. Sandilands, FionaM Reid, R.N.M. Macsween |
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| Rok vydání: | 1980 |
| Předmět: |
Adult
Male Rosette Formation Lymphocyte Mitochondria Liver Antigen-Antibody Complex Receptors Fc Serology Immune system Primary biliary cirrhosis Medicine Humans Lymphocytes Receptor Aged Autoantibodies Mechanism (biology) business.industry Liver Cirrhosis Biliary General Medicine Middle Aged medicine.disease digestive system diseases In vitro Immune complex medicine.anatomical_structure Immunoglobulin G Immunology Female business |
| Zdroj: | Lancet (London, England). 2(8184) |
| ISSN: | 0140-6736 |
| Popis: | 20 patients with primary biliary cirrhosis (PBC) had circulating IgG-containing immune complexes. These complexes bind to lymphocyte Fcγ-receptors in vitro; there was also evidence for in-vivo binding. Such in-vivo binding to T and K lymphocytes may exert an immunomodulatory effect on these cells, and may also explain some of the serological and cellular abnormalities in PBC. |
| Databáze: | OpenAIRE |
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