Effect of omeprazole and cimetidine on prepyloric gastric ulcer: double blind comparative trial
| Autor: | Flemming Bendtsen, S J Rune, Peter Bytzer, H. R. Wulff, T Havelund, Karsten Lauritsen, L Astrup, L S Laursen, J H Olsen, J Linde |
|---|---|
| Rok vydání: | 1988 |
| Předmět: |
Adult
Male medicine.medical_specialty medicine.drug_class medicine.medical_treatment Proton-pump inhibitor Gastroenterology law.invention Random Allocation Randomized controlled trial Double-Blind Method law Internal medicine medicine Humans Stomach Ulcer Cimetidine Omeprazole Aged Aged 80 and over Chemotherapy Clinical Trials as Topic Intention-to-treat analysis business.industry Stomach Middle Aged Clinical trial medicine.anatomical_structure Female business medicine.drug Research Article |
| Zdroj: | Gut. 29(2) |
| ISSN: | 0017-5749 |
| Popis: | We conducted a six week double blind randomised study of 176 patients with prepyloric gastric ulcer to determine whether the proton pump inhibitor, omeprazole 30 mg daily would accelerate healing and pain relief, as compared with cimetidine 1 g daily. At two, four, and six weeks after entry ulcers healed in a larger percentage of patients treated with omeprazole (54, 81, and 86%) than of those treated with cimetidine (39, 73, and 78%) ('intention to treat' cohort; p less than 0.05 at two weeks). A higher proportion of patients on omeprazole became free of pain during the first week of treatment (p less than 0.05). No major clinical or biochemical side effects were noted. Omeprazole is an efficient treatment for patients with prepyloric gastric ulcers. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|