Early predictors of renal outcome in patients with proliferative lupus nephritis: a 36-month cohort study
| Autor: | José António Pereira da Silva, Alexandre E Voskuyl, Luís Inês, Mariana Luís, Irene E. M. Bultink |
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| Přispěvatelé: | Rheumatology, AII - Inflammatory diseases, AMS - Musculoskeletal Health, AMS - Rehabilitation & Development |
| Rok vydání: | 2021 |
| Předmět: |
Adult
Male medicine.medical_specialty Lupus nephritis 030204 cardiovascular system & hematology Gastroenterology Young Adult 03 medical and health sciences 0302 clinical medicine Rheumatology Internal medicine medicine Humans Pharmacology (medical) Survival analysis Retrospective Studies 030203 arthritis & rheumatology Kidney Univariate analysis Proteinuria business.industry Remission Induction Hazard ratio Retrospective cohort study Induction Chemotherapy Middle Aged Symptom Flare Up medicine.disease Lupus Nephritis medicine.anatomical_structure Drug Therapy Combination Female medicine.symptom business Cohort study |
| Zdroj: | Rheumatology (Oxford, England), 60(11), 5134-5141. Oxford University Press Luís, M S F, Bultink, I E M, da Silva, J A P, Voskuyl, A E & Inês, L S 2021, ' Early predictors of renal outcome in patients with proliferative lupus nephritis : a 36-month cohort study ', Rheumatology (Oxford, England), vol. 60, no. 11, pp. 5134-5141 . https://doi.org/10.1093/rheumatology/keab126, https://doi.org/10.1093/rheumatology/keab126 |
| ISSN: | 1462-0332 1462-0324 |
| Popis: | Objectives To identify predictors of complete renal response (CRR) and renal flares in SLE patients with active proliferative LN. Methods This was a retrospective cohort study over 36 months including patients with biopsy-proven proliferative LN (class III/IV), from two European tertiary centres. CRR and renal flare were defined as proteinuria 1 g/day after CRR attainment, respectively. Demographic, clinical and analytic parameters were evaluated as early predictors of renal outcome, using survival analysis. Candidate variables were tested as predictors for CRR at time 0, 3 and 6 months after starting induction treatment. Potential predictors for renal flare were evaluated at time of reaching CRR. Variables with P Results We included 104 patients [81.7% female, mean (s.d.) age at baseline 32.0 (13.3) years]. Over follow-up, 91.7% reached CRR, within a median time of 6.0 months. Proteinuria Conclusion In patients with SLE and proliferative LN, factors assessed at baseline and 3 months from starting induction treatment can predict CRR and renal flares once CRR is achieved. |
| Databáze: | OpenAIRE |
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