Microstructural white matter brain abnormalities in patients with idiopathic fecal incontinence
| Autor: | H S Jorgensen, Janusiya Anajan Muthulingam, S Haas, Asbjørn Mohr Drewes, Søren Laurberg, Tine Maria Hansen, L Lundby, Jens Brøndum Frøkjær, Klaus Krogh |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Pathology
medicine.medical_specialty Physiology neuroplasticity Electroencephalography Lateralization of brain function White matter 03 medical and health sciences 0302 clinical medicine Fractional anisotropy medicine Journal Article Middle frontal gyrus Humans magnetic resonance imaging Aged medicine.diagnostic_test reorganization Endocrine and Autonomic Systems Superior longitudinal fasciculus Gastroenterology Brain Magnetic resonance imaging Middle Aged diffusion tensor imaging White Matter fecal incontinence medicine.anatomical_structure Diffusion Magnetic Resonance Imaging Diffusion Tensor Imaging 030211 gastroenterology & hepatology Female Psychology 030217 neurology & neurosurgery Fecal Incontinence Diffusion MRI |
| Zdroj: | Muthulingam, J, Haas, S, Hansen, T M, Laurberg, S, Lundby, L, Jørgensen, H S, Drewes, A M, Krogh, K & Frøkjaer, J B 2018, ' Microstructural white matter brain abnormalities in patients with idiopathic fecal incontinence ', Neurogastroenterology and Motility, vol. 30, no. 1, e13164, pp. 1-8 . https://doi.org/10.1111/nmo.13164 Muthulingam, J, Haas, S, Hansen, T M, Laurberg, S, Lundby, L, Jørgensen, H S, Drewes, A M, Krogh, K & Frøkjaer, J B 2018, ' Microstructural white matter brain abnormalities in patients with idiopathic fecal incontinence ', Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society, vol. 30, no. 1, e13164 . https://doi.org/10.1111/nmo.13164 |
| Popis: | BACKGROUND: Abnormal central nervous system processing of visceral sensation may be a part of the pathogenesis behind idiopathic fecal incontinence (IFI). Our aim was to characterize brain differences in patients with IFI and healthy controls by means of structural magnetic resonance imaging (MRI) and diffusion tensor imaging (DTI).METHODS: In 21 female patients with IFI and 15 female healthy controls, whole-brain structural differences in gray matter volume (GMV), cortical thickness, and white matter tracts fractional anisotropy (FA) were quantified. For this purpose, we used voxel-based morphometry, surface based morphometry and tract-based spatial statistic, respectively. Furthermore, associations between structural brain characteristics and latencies of rectal sensory evoked electroencephalography potentials were determined.KEY RESULTS: Compared to healthy controls, IFI patients had significantly reduced FA values, reflecting reduced white matter tract integrity, in the left hemisphere superior longitudinal fasciculus (SLF), posterior thalamic radiation, and middle frontal gyrus (MFG), all PCONCLUSIONS & INFERENCES: This explorative study suggests that IFI patients have no macrostructural brain changes, but exhibit microstructural changes in white matter tracts relevant for sensory processing. The clinical relevance of this finding is supported by its correlations with prolonged latencies of cortical potentials evoked by rectal stimulation. This supports the theories of central nervous system changes as part of the pathogenesis in IFI patients. |
| Databáze: | OpenAIRE |
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