Association of miR-21-5p, miR-122-5p, and miR-320a-3p with 90-Day Mortality in Cardiogenic Shock

Autor: Yvan Devaux, Heli Tolppanen, Ilkka Tikkanen, Tuukka Tarvasmäki, Veli-Pekka Harjola, Päivi Lakkisto, Johan Lassus, Melanie Vausort, Mikko Hänninen, Alessandro Sionis, Heli Segersvärd, Toni Jäntti
Přispěvatelé: HUS Heart and Lung Center, Kardiologian yksikkö, University of Helsinki, Helsinki University Hospital Area, Clinicum, HUS Abdominal Center, Department of Medicine, Nefrologian yksikkö, HUS Emergency Medicine and Services, HUSLAB, Department of Clinical Chemistry and Hematology
Rok vydání: 2020
Předmět:
BIOMARKER
0301 basic medicine
Male
MIRNA-21
030204 cardiovascular system & hematology
Gastroenterology
0302 clinical medicine
Myocardial infarction
Spectroscopy
microRNA
Cardiogenic shock
Hazard ratio
cardiogenic shock
General Medicine
Middle Aged
APOPTOSIS
3. Good health
Computer Science Applications
Up-Regulation
HEART
Biomarker (medicine)
Female
Risk assessment
EXPRESSION
ACUTE MYOCARDIAL-INFARCTION
medicine.medical_specialty
Acute coronary syndrome
Shock
Cardiogenic
Renal function
Catalysis
Article
Inorganic Chemistry
03 medical and health sciences
CIRCULATING MICRORNAS
Internal medicine
MANAGEMENT
INJURY
medicine
Humans
Physical and Theoretical Chemistry
Acute Coronary Syndrome
PLASMA-LEVELS
Molecular Biology
Genetic Association Studies
Aged
business.industry
Organic Chemistry
3126 Surgery
anesthesiology
intensive care
radiology
medicine.disease
Survival Analysis
mortality
Confidence interval
MicroRNAs
030104 developmental biology
Multivariate Analysis
1182 Biochemistry
cell and molecular biology
prognosis
business
Biomarkers
Zdroj: International Journal of Molecular Sciences
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
r-IIB SANT PAU: Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)
Volume 21
Issue 21
Dipòsit Digital de Documents de la UAB
Universitat Autònoma de Barcelona
r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
instname
ISSN: 1422-0067
Popis: Cardiogenic shock (CS) is a life-threatening emergency. New biomarkers are needed in order to detect patients at greater risk of adverse outcome. Our aim was to assess the characteristics of miR-21-5p, miR-122-5p, and miR-320a-3p in CS and evaluate the value of their expression levels in risk prediction. Circulating levels of miR-21-5p, miR-122-5p, and miR-320a-3p were measured from serial plasma samples of 179 patients during the first 5–10 days after detection of CS, derived from the CardShock study. Acute coronary syndrome was the most common cause (80%) of CS. Baseline (0 h) levels of miR-21-5p, miR-122-5p, and miR-320a-3p were all significantly elevated in nonsurvivors compared to survivors (p <
0.05 for all). Above median levels at 0h of each miRNA were each significantly associated with higher lactate and alanine aminotransferase levels and decreased glomerular filtration rates. After adjusting the multivariate regression analysis with established CS risk factors, miR-21-5p and miR-320a-3p levels above median at 0 h were independently associated with 90-day all-cause mortality (adjusted hazard ratio 1.8 (95% confidence interval 1.1–3.0), p = 0.018
adjusted hazard ratio 1.9 (95% confidence interval 1.2–3.2), p = 0.009, respectively). In conclusion, circulating plasma levels of miR-21-5p, miR-122-5p, and miR-320a-3p at baseline were all elevated in nonsurvivors of CS and associated with markers of hypoperfusion. Above median levels of miR-21-5p and miR-320a-3p at baseline appear to independently predict 90-day all-cause mortality. This indicates the potential of miRNAs as biomarkers for risk assessment in cardiogenic shock.
Databáze: OpenAIRE
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