Old but Gold: Tracking the New Guise of Histone Deacetylase 6 (HDAC6) Enzyme as a Biomarker and Therapeutic Target in Rare Diseases
| Autor: | Stefania Butini, Giuseppe Campiani, Simone Brogi, Margherita Brindisi, Sandra Gemma, A Prasanth Saraswati |
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| Přispěvatelé: | Brindisi, Margherita, Saraswati, A Prasanth, Brogi, Simone, Gemma, Sandra, Butini, Stefania, Campiani, Giuseppe |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Rett syndrome
medicine.disease_cause Histone Deacetylase 6 Cell Line Epigenesis Genetic Mice Rare Diseases Ubiquitin Drug Discovery medicine Animals Humans Epigenetics biology Chemistry HDAC6 medicine.disease Histone Deacetylase Inhibitors Histone Acetylation biology.protein Cancer research Molecular Medicine Histone deacetylase Carcinogenesis Protein Processing Post-Translational Biomarkers |
| Popis: | Epigenetic regulation orchestrates many cellular processes and greatly influences key disease mechanisms. Histone deacetylase (HDAC) enzymes play a crucial role either as biomarkers or therapeutic targets owing to their involvement in specific pathophysiological pathways. Beyond their well-characterized role as histone modifiers, HDACs also interact with several nonhistone substrates and their increased expression has been highlighted in specific diseases. The HDAC6 isoform, due to its unique cytoplasmic localization, modulates the acetylation status of tubulin, HSP90, TGF-β, and peroxiredoxins. HDAC6 also exerts noncatalytic activities through its interaction with ubiquitin. Both catalytic and noncatalytic functions of HDACs are being actively studied in the field of specific rare disorders beyond the well-established role in carcinogenesis. This Perspective outlines the application of HDAC(6) inhibitors in rare diseases, such as Rett syndrome, inherited retinal disorders, idiopathic pulmonary fibrosis, and Charcot-Marie-Tooth disease, highlighting their therapeutic potential as innovative and targeted disease-modifying agents. |
| Databáze: | OpenAIRE |
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