Plasma BDNF is reduced among middle-aged and elderly women with impaired insulin function: Evidence of a compensatory mechanism
Autor: | Hannah Bruehl, Antonio Convit, Stephen J. Oliver, Jason Hassenstab, Vanessa Starr, Pauline McHugh, Elizabeth Javier, Alyssa Arentoft, Aziz Tirsi, Victoria Sweat |
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Jazyk: | angličtina |
Rok vydání: | 2009 |
Předmět: |
Male
medicine.medical_specialty Cognitive Neuroscience medicine.medical_treatment Experimental and Cognitive Psychology Enzyme-Linked Immunosorbent Assay Type 2 diabetes Neuropsychological Tests Article Developmental psychology Insulin resistance Cognition Arts and Humanities (miscellaneous) Memory Internal medicine Diabetes mellitus Developmental and Educational Psychology medicine Humans Aged Brain-derived neurotrophic factor Analysis of Variance Sex Characteristics Insulin Brain-Derived Neurotrophic Factor Patient Selection Age Factors Type 2 Diabetes Mellitus Middle Aged medicine.disease Neuropsychology and Physiological Psychology Endocrinology Diabetes Mellitus Type 2 Blood sugar regulation Female Insulin Resistance Psychology Sex characteristics |
Popis: | Brain-derived neurotrophic factor (BDNF) plays a regulatory role in neuronal differentiation and synaptic plasticity and has been linked to glucose regulation and cognition. Associations among plasma BDNF, cognition, and insulin function were explored. Forty-one participants with impaired insulin function (IIF), ranging from insulin resistance to type 2 diabetes mellitus (T2DM), were matched with 41 healthy controls on gender, age, education, and IQ. Participants received complete medical, neurological, psychiatric, and neuropsychological evaluations. IIF individuals had significantly lower plasma BDNF levels than controls, particularly females, and higher BDNF levels were associated with poorer explicit memory in IIF females, suggesting that higher levels within this group may reflect the body’s efforts to respond to damage. After accounting for age, education, and HbA1c, BDNF significantly predicted 13.1%–23.5% of the variance in explicit memory in IIF women. These findings suggest that BDNF elevations within diseased groups may not always be a marker of health. |
Databáze: | OpenAIRE |
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