Prevalence of red blood cell antibodies in whole blood donors: A single-centre experience in north India
| Autor: | Archana Solanki, Tulika Chandra, Ashutosh Kumar Singh |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Male
0301 basic medicine medicine.medical_specialty Erythrocytes Blood transfusion medicine.medical_treatment Alloantibody identification 030106 microbiology Population India lcsh:Medicine Blood Donors antibody screening General Biochemistry Genetics and Molecular Biology red blood cell panel 03 medical and health sciences haemolytic transfusion reaction 0302 clinical medicine Isoantibodies ABO blood group system Internal medicine Prevalence medicine Humans 030212 general & internal medicine Child education Whole blood education.field_of_study biology Red Cell business.industry lcsh:R Autoantibody General Medicine Red blood cell medicine.anatomical_structure whole blood donors blood transfusion safety biology.protein Original Article Female red cell alloimmunization Antibody business alloantibody identification - antibody screening - blood transfusion safety - haemolytic transfusion reaction - red blood cell panel - red cell alloimmunization - whole blood donors |
| Zdroj: | Indian Journal of Medical Research, Vol 152, Iss 3, Pp 280-284 (2020) The Indian Journal of Medical Research |
| ISSN: | 0971-5916 |
| Popis: | Background & objectives: Blood transfusion therapy involves multiple steps to ensure selection of safe blood component for transfusion. This includes testing for infectious markers, full ABO compatibility, free from any clinically significant red cell antibodies and acceptable donor's red cell survival rates without destruction of recipient's red cells. The red cell antibodies present in healthy blood donors can cause severe haemolytic transfusion reaction, especially in massive blood transfusion recipients and paediatric patients. Hence, screening of red cell antibodies in donor blood is important to provide compatible blood products and to avoid haemolytic transfusion reactions in susceptible patient population. This study was planned to assess prevalence, aetiology and type of unexpected red cell antibodies in a large number of whole blood donor population in north India. Methods: This three-year prospective observational study included blood donor samples for antibody screening from January 2015 to December 2017. A total of 166,803 healthy blood donors including 156,128 (93.6%) males and 10,675 (6.4%) females were screened. Results: The prevalence of red cell antibodies was 0.17 per cent in our donor population. Of the total 286 donors with red cell antibodies, 248 (86.7%) had alloantibodies, 30 (10.5%) had autoantibodies and eight donors (2.8%) showed positive antibody screening with inconclusive results. Interpretation & conclusions: Alloimmunization to red cell antigens is a challenging task for current transfusion practices. The antibody screening in blood donors may improve the quality and safety of blood transfusion in the recipients. It also reduces the risk of complications from incompatible blood transfusions. |
| Databáze: | OpenAIRE |
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