Application of smooth particle hydrodynamics method for modelling blood flow with thrombus formation
| Autor: | Mohammed Al-Saad, Anas Obeidat, Stéphane Bordas, Sivakumar Kulasegaram, C. A. Suarez |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Materials science
0206 medical engineering Flow (psychology) 02 engineering and technology Multidisciplinaire généralités & autres [C99] [Ingénierie informatique & technologie] Smoothed-particle hydrodynamics 03 medical and health sciences symbols.namesake medicine Thrombus 030304 developmental biology 0303 health sciences Multidisciplinary general & others [C99] [Engineering computing & technology] Reynolds number Blood flow Mechanics medicine.disease 020601 biomedical engineering Thrombosis Computer Science Applications medicine.anatomical_structure Modeling and Simulation symbols Particle Software Blood vessel |
| ISSN: | 1526-1506 |
| Popis: | Thrombosis plays a crucial role in atherosclerosis or in haemostasis when a blood vessel is injured. This article focuses on using a meshless particle-based Lagrangian numerical technique, the smoothed particles hydrodynamic (SPH) method, to study the flow behaviour of blood and to explore the flow parameters that induce formation of a thrombus in a blood vessel. Due to its simplicity and effectiveness, the SPH method is employed here to simulate the process of thrombogenesis and to study the effect of various blood flow parameters. In the present SPH simulation, blood is modelled by two sets of particles that have the characteristics of plasma and of platelet, respectively. To simulate coagulation of platelets which leads to a thrombus, the so-called adhesion and aggregation mechanisms of the platelets during this process are modelled by an inter-particle force model. The transport of platelets in the flowing blood, platelet adhesion and aggregation processes are coupled with viscous blood flow for various low Reynolds number scenarios. The numerical results are compared with the experimental observations and a good agreement is found between the simulated and experimental results. |
| Databáze: | OpenAIRE |
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