| Popis: |
Artificial light at night (ALAN) exposure is associated with the disruption of human circadian processes. Through numerous pathophysiological mechanisms such as melatonin dysregulation, it is hypothesised that ALAN exposure is involved in asthma and allergy, mental illness, and cancer outcomes. There are numerous existing studies considering these relationships; however, a critical appraisal of available evidence on health outcomes has not been completed. Due to the prevalence of ALAN exposure and these outcomes in society, it is critical that current evidence of their association is understood. Therefore, this systematic scoping review will aim to assess the association between ALAN exposure and asthma and allergy, mental health, and cancer outcomes. This systematic scoping review will be conducted in accordance with the Preferred Reporting Items for Systematic reviews and Meta-Analyses statement. We will search bibliographic databases, registries, and references. We will include studies that have described potential sources of ALAN exposure (such as shift work or indoor and outdoor exposure to artificial light); have demonstrated associations with either allergic conditions (including asthma), mental health, or cancer-related outcomes; and are published in English in peer-reviewed journals. We will conduct a comprehensive literature search, title and abstract screening, full-text review, and data collection and analysis for each outcome separately. This study will be partially funded by a non-exclusive research grant from Synergy Respiratory & Cardiac Care (to Paige Lacy), and internal research support from Apollo Gleneagles Hospital (to Saibal Moitra). Ana Adan and Jose Francisco Navarro are supported by the grant PID2020-117767GB-I00 of the Spanish Ministry of Science and Innovation (MCIN/AEI/10.13039/501100011033). Hannah Durrington is supported by a Medical Research Council Clinician Scientist Fellowship (MRC-CSF-MR/V029460/1). |
