The triglyceride to HDL-cholesterol ratio and chronic graft failure in renal transplantation

Autor: Josephine L. C. Anderson, Stephan J. L. Bakker, Uwe J. F. Tietge
Přispěvatelé: Groningen Institute for Organ Transplantation (GIOT), Groningen Kidney Center (GKC), Center for Liver, Digestive and Metabolic Diseases (CLDM)
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Adult
CHRONIC KIDNEY-DISEASE
medicine.medical_specialty
HDL
Endocrinology
Diabetes and Metabolism
medicine.medical_treatment
Renal function
ANTIINFLAMMATORY FUNCTION
HDL-C ratio
030204 cardiovascular system & hematology
Kidney
Gastroenterology
Triglyceride
03 medical and health sciences
0302 clinical medicine
INFLAMMATION
Internal medicine
Diabetes mellitus
Internal Medicine
medicine
Humans
030212 general & internal medicine
Longitudinal Studies
Dialysis
Triglycerides
Chronic graft failure
METABOLIC SYNDROME
Transplantation
Nutrition and Dietetics
Proportional hazards model
business.industry
Hazard ratio
Cholesterol
HDL
CARDIOVASCULAR-DISEASE RISK
Middle Aged
medicine.disease
Kidney Transplantation
REMNANT CHOLESTEROL
NONFASTING TRIGLYCERIDES
Dyslipidemia
DENSITY-LIPOPROTEIN CHOLESTEROL
RICH LIPOPROTEINS
FATTY-ACIDS
Metabolic syndrome
Cardiology and Cardiovascular Medicine
business
Zdroj: Journal of Clinical Lipidology, 15(2), 301-310. ELSEVIER SCIENCE INC
ISSN: 1933-2874
Popis: BACKGROUND: Transplant vasculopathy (TV) is a major contributing factor to chronic graft failure in renal transplant recipients (RTR). TV lesions resemble atherosclerosis in several ways, and it is plausible to believe that some risk factors influence both atherosclerotic plaque formation and formation of TV. OBJECTIVE: The objective of this prospective longitudinal study was to determine if dyslipidemia reflected by the triglyceride (TG)/high-density lipoprotein cholesterol (HDL-C) ratio is prospectively associated with death censored chronic graft failure in RTR.METHOD: 454 prospectively included RTR with a functioning graft for at least one year, were followed for a median of 7 years. RTR were matched based on propensity scores to avoid potential confounding and subsequently the association of the TG/HDL-C ratio with the endpoint chronic graft failure, defined as return to dialysis or re-transplantation, was investigated.RESULTS: Linear regression analysis showed that concentration of insulin, male gender, BMI and number of antihypertensives predict the TG/HDL-C ratio. Cox regression showed that the TG/HDL-C ratio is associated with chronic graft failure (HR = 1.43, 95%CI = 1.12-1.84, p = 0.005) in competing risk analysis for mortality. Interaction testing indicated that the relationship of the TG/HDL-C ratio with graft failure is stronger in subjects with a higher insulin concentration.CONCLUSION: Our results demonstrate that the TG/HDL-C ratio has the potential to act as a predictive clinical biomarker. Furthermore, there is a need for closer attention to lipid management in RTR in clinical practice with a focus on triglyceride metabolism. (c) 2021 National Lipid Association. Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
Databáze: OpenAIRE
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