Steatotic and Steatohepatitic Hepatocellular Carcinomas Features in a Series With Predominantly Viral Etiology
| Autor: | Deniz Nart, Ulus Salih Akarca, Murat Zeytunlu, Zeki Karasu, Mehmet Orman, Umut Aykutlu, Fulya Gunsar, Asuman Argon, Funda Yilmaz, Sezgin Ulukaya |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Adult
Male Alcoholic liver disease medicine.medical_specialty Carcinoma Hepatocellular steatohepatitis Gastroenterology metabolic syndrome Pathology and Forensic Medicine Internal medicine steatohepatitic hepatocellular carcinoma Diagnosis medicine steatosis Humans Serum amyloid A Variant neoplasms Aged Retrospective Studies business.industry Protein Liver Neoplasms hepatocellular carcinoma Middle Aged HCCS Hepatitis B medicine.disease digestive system diseases Fatty Liver Liver Cirrhosis Hepatocellular carcinoma Etiology Female Surgery Anatomy Steatosis Steatohepatitis business Immunostaining |
| Popis: | 105th Annual Meeting of the United-States-and-Canadian-Academy-of-Pathology (USCAP) -- MAR 12-18, 2016 -- Seattle, WA Hepatocellular carcinomas (HCCs) with steatohepatitis and steatosis are reported with varying definitions and clinicopathologic features. We aimed to search the attributes of steatohepatitic hepatocellular carcinoma (SH-HCC) and steatotic-HCC in our series. A retrospective clinicopathologic analyses of 150 HCCs and immunostaining for C-reactive protein (CRP) and serum amyloid A (SAA) were performed. Tumors were reclassified as all SH-HCC, limited SH-HCC, typical SH-HCC (steatohepatitic features in >5%, 5% to 50%, and >= 50% of the tumor, respectively), steatotic-HCC, and classic HCC (C-HCC). Group comparisons were made using Kruskal-Wallis and Kaplan-Meier tests. The background etiology in all SH-HCCs was pure viral in 51.4%, nonalcoholic steatohepatitis (NASH)/alcoholic liver disease (ALD) alone/mixed in 34.3%, and unidentified in normal liver in 14.3%. All SH-HCCS (n=35, 23.3%) and typical SH-HCCs (n=13, 8.6%) had higher NASH/ALD. Limited SH-HCCs (n=22, 14.6%) had higher ALD (all P0.05). SH-HCC is heterogenous in terms of underlying etiologies, and can be seen in NASH/ALD, pure viral and noncirrhotic/normal background. The >= 50% cutoff for the definition of SH-HCC can lead to overlook ALD-related SH-HCC. Steatotic-HCC seems more similar to C-HCC rather than SH-HCC, but none of them feature as a different prognostic group. US & Canadian Acad Pathol Ege University Scientific Research Projects Fund [2.101.2014.0071] Supported by Ege University Scientific Research Projects Fund (Project No: 2.101.2014.0071). The authors have disclosed that they have no significant relationships with, or financial interest in, any commercial companies pertaining to this article. |
| Databáze: | OpenAIRE |
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