Risk Factors for Cytarabine-Induced Cutaneous Toxicity in Patients with Haematological Malignancies
| Autor: | Masao Mizuki, Kayoko Morio, Takashi Sozu, Etsuko Uejima |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Male
Oncology medicine.medical_specialty Myeloid Skin Diseases Risk Factors hemic and lymphatic diseases Internal medicine Drug Discovery medicine Humans Pharmacology (medical) Retrospective Studies Pharmacology business.industry Lymphoma Non-Hodgkin Cytarabine Retrospective cohort study General Medicine Odds ratio Middle Aged medicine.disease Confidence interval Lymphoma Leukemia Myeloid Acute Leukemia Infectious Diseases medicine.anatomical_structure Hematologic Neoplasms Toxicity Female business medicine.drug |
| Zdroj: | Chemotherapy. 60:168-173 |
| ISSN: | 1421-9794 0009-3157 |
| DOI: | 10.1159/000371839 |
| Popis: | Background: The risk factors for cytarabine (Ara-C)-induced cutaneous toxicity are unclear. Methods: We retrospectively reviewed the medical charts of patients with haematopoietic malignancies treated with Ara-C and examined risk factors for Ara-C-induced cutaneous toxicity. Results: We reviewed 114 patients (76 men, 38 women) and found that 47 patients (41.2%) experienced cutaneous toxicity. In 93 patients (81.6%) with non-Hodgkin's lymphoma (NHL) and acute myeloid leukaemia (AML), the toxicity was significantly associated with the cancer type [AML/NHL: odds ratio (OR) = 4.84; 95% confidence interval (CI) = 1.99-11.81; p = 0.001], age (Conclusion: AML, age |
| Databáze: | OpenAIRE |
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