Effectiveness of an Integrated Intervention Program for Alcoholism: Electrophysiological Findings
| Autor: | G S Ravi, Keshav J. Kumar, Bangalore N. Roopesh, Rajesh Kumar, Vivek Benegal |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Psychiatry
medicine.medical_specialty Intervention program alcoholism Resting state fMRI business.industry SOG RC435-571 Vulnerability 030508 substance abuse Original Articles EEG/ERPs 030205 complementary & alternative medicine alcohol No-Go 03 medical and health sciences Clinical Psychology Psychiatry and Mental health Electrophysiology 0302 clinical medicine Physical medicine and rehabilitation medicine 0305 other medical science business psychological phenomena and processes flanker |
| Zdroj: | Indian Journal of Psychological Medicine, Vol 43 (2021) Indian Journal of Psychological Medicine |
| ISSN: | 0975-1564 0253-7176 |
| Popis: | Background: Neuroelectrophysiological measures such as electroencephalograms (EEGs) in resting state and event-related potentials (ERPs) provide valuable information about the vulnerability and treatment-related changes in persons with alcoholism. This study examined the effectiveness of an Integrated Intervention Program for Alcoholism (IIPA) using electrophysiological measures. Methods: Fifty individuals with early onset of alcohol dependence participated. They were grouped randomly into two: the treatment as usual (TAU) group and the treatment group, matched on age (±1 year) and education (±1 year). eyes closed and resting state EEGs and ERPs on cognitive tasks (flanker task, alcohol Go/No-Go task, and single outcome gambling task) were recorded before and after treatment. The TAU group received pharmacotherapy, six days/week yoga sessions, and three sessions/week group therapy on relapse prevention while the treatment group received IIPA along with usual treatment (except yoga) for 18 days. Results: There was no significant difference between the groups pre-treatment. RM-ANOVA for pre- and post-treatment stages showed a significant difference between the two groups in the absolute power of alpha, beta, theta, and delta, during eye closure, in the resting-state EEGs. The treatment group showed significantly larger N200/N2 amplitude in congruent and incongruent conditions (flanker task), N200/N2 amplitude for alcohol No-Go, P300/P3 amplitude for neutral No-Go on alcohol Go/No-Go task, and outcome-related positivity (ORP) amplitude on single outcome gambling task. Conclusion: This exploratory study suggests that IIPA is effective for enhancing relaxation state and attentiveness, decreasing hyperarousal, and ameliorating neurocognitive dysfunctions of conflict-monitoring, response inhibition, and reward processing. |
| Databáze: | OpenAIRE |
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