Effect of Lactobacillus rhamnosus Probiotic in Early Pregnancy on Plasma Conjugated Bile Acids in a Randomised Controlled Trial
| Autor: | Rinki Murphy, Kristin Wickens, Thorsten Stanley, Julian Crane, Edwin A. Mitchell, Fabrice Merien, Christine Barthow, Peter Stone, Yutao Chen, Jun Lu, Robyn Maude |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Blood Glucose
0301 basic medicine medicine.medical_treatment Mass Spectrometry chemistry.chemical_compound 0302 clinical medicine High-density lipoprotein Pregnancy Insulin Nutrition and Dietetics biology Lacticaseibacillus rhamnosus food and beverages Middle Aged Lipids Gestational diabetes Gestation Female gestational diabetes lcsh:Nutrition. Foods and food supply Adult medicine.medical_specialty education Glycocholic acid 030209 endocrinology & metabolism lcsh:TX341-641 Carbohydrate metabolism Article Bile Acids and Salts Young Adult 03 medical and health sciences Insulin resistance Lactobacillus rhamnosus Internal medicine medicine Humans insulin sensitivity bile acids business.industry medicine.disease biology.organism_classification LC-MS Diabetes Gestational 030104 developmental biology Endocrinology chemistry probiotics Dietary Supplements conjugated bile acids business randomised controlled trial Biomarkers Chromatography Liquid Food Science |
| Zdroj: | Nutrients, Vol 13, Iss 209, p 209 (2021) Nutrients Volume 13 Issue 1 |
| ISSN: | 2072-6643 |
| Popis: | We have previously shown that probiotic supplementation with Lactobacillus rhamnosus HN001 (HN001) led to a reduced incidence of gestational diabetes mellitus (GDM). Here we investigate whether HN001 supplementation resulted in alterations in fasting lipids, insulin resistance, or bile acids (BAs) during pregnancy. Fasting plasma samples collected at 24&ndash 30 weeks&rsquo gestation, from 348 women randomised at 14&ndash 16 weeks&rsquo gestation to consume daily probiotic HN001 (n = 172) or a placebo (n = 176) were analysed for lipids, insulin, glucose and BAs. Women supplemented with HN001 had lower fasting glucose compared with placebo (p = 0.040), and lower GDM. Significant differences were found in fasting insulin, HOMA-IR, low density lipoprotein-cholesterol (LDL-c), high density lipoprotein (HDL)-c, triglycerides, total cholesterol, and BAs by GDM status. Lower fasting conjugated BAs were seen in women receiving HN001. A significant decrease of glycocholic acid (GCA) was found in older (age &ge 35) women who received HN001 (p = 0.005), while GDM women showed significant reduced taurodeoxycholic acid (TDCA) (p = 0.018). Fasting conjugated BA was positively correlated with fasting glucose (r = 0.136, p = 0.020) and fasting insulin (r = 0.113, p = 0.036). Probiotic HN001 supplementation decreases conjugated BAs and might play a role in the improvement of glucose metabolism in women with pregnancy. |
| Databáze: | OpenAIRE |
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