Coming from the Wild: Multidrug Resistant Opportunistic Pathogens Presenting a Primary, Not Human-Linked, Environmental Habitat

Autor: Luz Edith Ochoa-Sánchez, Sara Hernando-Amado, Pablo Laborda, José L. Martínez, Teresa Gil-Gil, Fernando Sanz-García
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Acinetobacter baumannii
0301 basic medicine
Shewanella
medicine.drug_class
QH301-705.5
Stenotrophomonas maltophilia
030106 microbiology
Antibiotics
Review
Burkholderia cepacia
Opportunistic Infections
Biology
medicine.disease_cause
Catalysis
Inorganic Chemistry
03 medical and health sciences
Antibiotic resistance
opportunistic pathogens
environmental bacteria
Drug Resistance
Multiple
Bacterial
MDR
medicine
Animals
Humans
One-Health
Physical and Theoretical Chemistry
Biology (General)
Molecular Biology
QD1-999
Ecosystem
Spectroscopy
Resistance (ecology)
Pseudomonas aeruginosa
Ecology
Organic Chemistry
General Medicine
biology.organism_classification
Computer Science Applications
Multiple drug resistance
intrinsic resistance
Chemistry
030104 developmental biology
One Health
Aeromonas
Bacteria
Zdroj: International Journal of Molecular Sciences, Vol 22, Iss 8080, p 8080 (2021)
International Journal of Molecular Sciences
ISSN: 1661-6596
1422-0067
Popis: The use and misuse of antibiotics have made antibiotic-resistant bacteria widespread nowadays, constituting one of the most relevant challenges for human health at present. Among these bacteria, opportunistic pathogens with an environmental, non-clinical, primary habitat stand as an increasing matter of concern at hospitals. These organisms usually present low susceptibility to antibiotics currently used for therapy. They are also proficient in acquiring increased resistance levels, a situation that limits the therapeutic options for treating the infections they cause. In this article, we analyse the most predominant opportunistic pathogens with an environmental origin, focusing on the mechanisms of antibiotic resistance they present. Further, we discuss the functions, beyond antibiotic resistance, that these determinants may have in the natural ecosystems that these bacteria usually colonize. Given the capacity of these organisms for colonizing different habitats, from clinical settings to natural environments, and for infecting different hosts, from plants to humans, deciphering their population structure, their mechanisms of resistance and the role that these mechanisms may play in natural ecosystems is of relevance for understanding the dissemination of antibiotic resistance under a One-Health point of view.
Databáze: OpenAIRE
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