Neoadjuvant radiotherapy of primary irresectable unicentric Castleman's disease: a case report and review of the literature
| Autor: | Jean-Paul de Zoete, Grard A. P. Nieuwenhuijzen, Iris A C de Vries, Marnix L M Lybeert, Thomas B J Demeyere, Marjolein M S van Acht |
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| Jazyk: | angličtina |
| Předmět: |
lcsh:Medical physics. Medical radiology. Nuclear medicine
medicine.medical_specialty Exophthalmos lcsh:R895-920 medicine.medical_treatment Case Report Hyperthyroidism lcsh:RC254-282 Abdomen medicine Humans Radiology Nuclear Medicine and imaging Neoadjuvant therapy Hyaline Aged POEMS syndrome Radiotherapy business.industry Castleman Disease Castleman disease Anemia Explorative laparotomy lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens medicine.disease Neoadjuvant Therapy Surgery Radiation therapy medicine.anatomical_structure Oncology Radiology Nuclear Medicine and imaging Female Radiology medicine.symptom Tomography X-Ray Computed business |
| Zdroj: | Radiation Oncology, Vol 5, Iss 1, p 7 (2010) Radiation Oncology (London, England) |
| ISSN: | 1748-717X |
| DOI: | 10.1186/1748-717x-5-7 |
| Popis: | Background Castleman disease (CD) is a rare benign disorder characterised by hyperplasia of lymphoid tissue that may develop at a single site or throughout the body. The etiology of this disorder is unclear, although the histopathological presentation can be differentiated into a hyaline vascular variant, a plasma cell variant and a mixed variant. Clinically, it has been recorded that 3 manifestations of CD are characterized: a localized unicentric type, a generalized multicentric type and a mixed form. Surgery remains the main treatment for resectable unicentric CD, since removal of the large node is possible without further complications. No consensus has been reached concerning the most adequate treatment for irresectable unicentric CD. Methods Case report of a 67 year old woman. Results This report, describes the case of a 67-year-old woman with unicentric Castleman disease located in the right lower abdomen. The patient had symptoms of fatigue, dyspnoea and pain in the right lower abdomen. Computed tomography (CT)- examination revealed a tumour, which had grown to form a close relationship with the common iliac vessels and the sacral bone. A Laparotomy procedure revealed that the tumour was an irresectable mass. Neo-adjuvant radiotherapy (40 Gy) was administered in order to downsize the tumour. Six weeks later a new CT-scan revealed a major reduction of the tumour, which enabled a successful radical resection of the tumour to be performed. Histopathological analysis of the tumour showed the hyaline vascular type of CD. Conclusions Neo-adjuvant radiotherapy should be considered in case of an irresectable unicentric CD. |
| Databáze: | OpenAIRE |
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