A flow-based synthesis of Imatinib: the API of Gleevec
| Autor: | Mark D. Hopkin, Ian R. Baxendale, Steven V. Ley |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Manual handling
Antineoplastic Agents Chronic myeloid leukaemia Piperazines Catalysis Leukemia Myelogenous Chronic BCR-ABL Positive hemic and lymphatic diseases Materials Chemistry medicine Humans Product formation Piperazine Chromatography Chemistry Metals and Alloys Imatinib General Chemistry Surfaces Coatings and Films Electronic Optical and Magnetic Materials Pyrimidines Imatinib mesylate Flow (mathematics) Benzamides Imatinib Mesylate Ceramics and Composites Dimethylamines medicine.drug |
| Zdroj: | Chemical Communications. 46:2450 |
| ISSN: | 1364-548X 1359-7345 |
| DOI: | 10.1039/c001550d |
| Popis: | A concise, flow-based synthesis of Imatinib, a compound used for the treatment of chronic myeloid leukaemia, is described whereby all steps are conducted in tubular flow coils or cartridges packed with reagents or scavengers to effect clean product formation. An in-line solvent switching procedure was developed enabling the procedure to be performed with limited manual handling of intermediates. |
| Databáze: | OpenAIRE |
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