Frizzled-4 C-terminus Distal to KTXXXW Motif is Essential for Normal Dishevelled Recruitment and Norrin-stimulated Activation of Lef/Tcf-dependent Transcriptional Activation
| Autor: | Shujuan Gao, Alexander C. Bertalovitz, Milly S. Pau, Hsien-yu Wang, Craig C. Malbon |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Frizzled animal structures FZD4 Short Report Biology Norrin Biochemistry Dishevelled 03 medical and health sciences helix VIII 0302 clinical medicine Molecular Biology carboxy-terminus G protein-coupled receptor chemistry.chemical_classification C-terminus Cell Biology Cell biology Frizzled-4 030104 developmental biology chemistry 030220 oncology & carcinogenesis embryonic structures |
| Zdroj: | Journal of Molecular Signaling; Vol 11 (2016); 1 Journal of Molecular Signaling |
| ISSN: | 1750-2187 |
| Popis: | The carboxy (C)-termini of G protein coupled receptors (GPCR) dictate essential functions. The KTXXXW motif C-terminus of Frizzleds (FZD) has been implicated in recruitment of Dishevelled (DVL). Through study of FZD4 and its associated ligand Norrin, we report that a minimum of three residues distal to the KTXXXW motif in the C-terminal tail of Frizzled-4 are essential for DVL recruitment and robust Lef/Tcf-dependent transcriptional activation in response to Norrin. |
| Databáze: | OpenAIRE |
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