A scalable controlled-release device for transscleral drug delivery to the retina
| Autor: | Takeaki Kawashima, Hideyuki Onami, Hirokazu Kaji, Norihiro Kumasaka, Yumi Ishikawa, Toshiaki Abe, Matsuhiko Nishizawa, Noriko Osumi, Nobuhiro Nagai |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Materials science
Blotting Western Biophysics Bioengineering macromolecular substances Polyethylene glycol Pharmaceutical formulation Retina Biomaterials chemistry.chemical_compound Drug Delivery Systems medicine Animals Humans Retinal pigment epithelium Brain-Derived Neurotrophic Factor Capsule Dextrans biochemical phenomena metabolism and nutrition equipment and supplies Controlled release medicine.anatomical_structure Membrane chemistry Mechanics of Materials Drug delivery Ceramics and Composites Microscopy Electron Scanning Collagen Rabbits Fluorescein-5-isothiocyanate Biomedical engineering |
| Zdroj: | Biomaterials. 32(7) |
| ISSN: | 1878-5905 |
| Popis: | A transscleral drug-delivery device, designed for the administration of protein-type drugs, that consists of a drug reservoir covered with a controlled-release membrane was manufactured and tested. The controlled-release membrane is made of photopolymerized polyethylene glycol dimethacrylate (PEGDM) that contains interconnected collagen microparticles (COLs), which are the routes for drug permeation. The results showed that the release of 40-kDa FITC-dextran (FD40) was dependent on the COL concentration, which indicated that FD40 travelled through the membrane-embedded COLs. Additionally, the sustained-release drug formulations, FD40-loaded COLs and FD40-loaded COLs pelletized with PEGDM, fine-tuned the release of FD40. Capsules filled with COLs that contained recombinant human brain-derived neurotrophic factor (rhBDNF) released bioactive rhBDNF in a manner dependent on the membrane COL concentration, as was found for FD40 release. When capsules were sutured onto sclerae of rabbit eyes, FD40 was found to spread to the retinal pigment epithelium. Implantation of the device was easy, and it did not damage the eye tissues. In conclusion, our capsule is easily modified to accommodate different release rates for protein-type drugs by altering the membrane COL composition and/or drug formulation and can be implanted and removed with minor surgery. The device thus has great potential as a conduit for continuous, controlled drug release. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect