Comparative pharmacokinetics of chlorphenesin carbamate and methocarbamol in man
| Autor: | Arlington A. Forist, Ray W. Judy |
|---|---|
| Rok vydání: | 1971 |
| Předmět: |
Adult
Male Methocarbamol Time Factors Chemistry Muscle Relaxants Central Pharmaceutical Science Absorption (skin) Serum concentration Pharmacology Chlorphenesin Kinetics Lag time Pharmacokinetics Oral administration Relative Volume Propylene Glycols medicine Chlorphenesin carbamate Humans Carbamates medicine.drug Half-Life |
| Zdroj: | Journal of pharmaceutical sciences. 60(11) |
| ISSN: | 0022-3549 |
| Popis: | Serum drug levels following oral administration of large single doses of chlorphenesin carbamate and methocarbamol were fitted to a one-compartment open model. The appearance of each drug was described by a short lag time followed by a rapid first-order absorption and attainment of maximum levels. No statistically significant differences were found between estimates of mean lag times (t0, 0.5 and 0.2 hr.), half-lives for absorption (t1/2, 0.4 and 0.6 hr), and times for attainment of maximum serum concentrations (tm, 1.9 and 1.4 hr.) for chlorphenesin carbamate and methocarbamol, respectively. Chlorphenesin carbamate was distributed throughout a significantly larger relative volume (1.27 versus 0.48 1./kg.) and yielded a correspondingly smaller maximum serum concentration (15.3 versus 29.8 mcg./ml., 2-g. dose). The mean biological half-life for chlorphenesin carbamate, 3.14 hr., was significantly greater than the value of 1.20 hr. obtained for methocarbamol. |
| Databáze: | OpenAIRE |
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