Biological monitoring of cobalt in hard metal factory workers
| Autor: | Andrea Princivalle, Luigi Perbellini, Ivo Iavicoli, Antonia Franceschi, Maurizio Manno, Marzia Cerpelloni |
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| Přispěvatelé: | Princivalle, Andrea, Iavicoli, Ivo, Cerpelloni, Marzia, Franceschi, Antonia, Manno, Maurizio, Perbellini, Luigi |
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Adult
Male Haemoglobin adduct Urinary system chemistry.chemical_element Urine 010501 environmental sciences 01 natural sciences Mass Spectrometry Excretion Hemoglobins Hard metal workers Occupational Exposure Biomonitoring Humans 0105 earth and related environmental sciences Whole blood Haemoglobin adducts Hard metal 010401 analytical chemistry Public Health Environmental and Occupational Health Oxides Elimination kinetics Cobalt Middle Aged Hard metal worker 0104 chemical sciences Blood chemistry Environmental chemistry Metallurgy Female Environmental Monitoring |
| Popis: | The main aim of this study was to investigate the cobalt (Co) concentrations in urine along 4 months and their relationship with Co concentrations in blood and haemoglobin (adducts) in 34 workers from a hard metal manufacturing plant where metallic Co and Co oxide were used. Furthermore, the excretion kinetics of Co was investigated and the half-lives of Co in blood, plasma and urine were calculated along 18 days of non-exposure in the same workers. Co was analysed, in all biological samples, by ICP/MS. Wide fluctuations in the urinary Co concentration were observed throughout the work shift and during the work week. A highly significant linear correlation was found between Co concentration (geometrical mean) in urine samples provided each Thursday (end shift) during 16 subsequent weeks and levels of Co-haemoglobin adducts or blood Co concentrations at the end of the same period. The Co elimination kinetics in globin calculated along 18 days without Co exposure was slow, being related to the physiological metabolism of haemoglobin, while in blood, plasma and urine Co half-lives were 12.3, 9.1 and 5.3 days, respectively. Co concentrations in haemoglobin or blood are highly related to the geometrical mean concentration of urinary Co when samples are collected weekly for several subsequent weeks. The biological monitoring of occupational exposure to Co in hard metal facilities provides reliable results by using the Co concentrations in haemoglobin or in whole blood. The urinary findings, though, do not show the same reliability because of their wide daily and weekly fluctuations. |
| Databáze: | OpenAIRE |
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