Corneal penetration of fluoroquinolones: aqueous humor concentrations after topical application of levofloxacin 0.5% and ofloxacin 0.3% eyedrops
| Autor: | Auli Ropo, Sven C. Kulus, Markus Roessler, Klaus Geldsetzer, Hans-Reinhard Koch |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
Ofloxacino
Male medicine.medical_specialty Corneal penetration Ofloxacin Anterior Chamber medicine.medical_treatment Administration Topical Aqueous humor Levofloxacin Aqueous Humor Cornea Ophthalmology medicine Humans Chromatography High Pressure Liquid Antibacterial agent Aged Phacoemulsification business.industry Cataract surgery Sensory Systems Anti-Bacterial Agents medicine.anatomical_structure Anesthesia Surgery Female Ophthalmic Solutions business medicine.drug |
| Zdroj: | Journal of cataract and refractive surgery. 31(7) |
| ISSN: | 0886-3350 |
| Popis: | Purpose To investigate the penetration of topically applied levofloxacin 0.5% and ofloxacin 0.3% eyedrops into the aqueous humor of patients having cataract surgery. Setting Hochkreuzklinik Eye Hospital, Bonn, Germany. Methods In this randomized, investigator-masked study, 69 patients received 4 drops of either levofloxacin 0.5% or ofloxacin 0.3% eyedrops within 1 hour (60 min, 45 min, 30 min, and 15 min) of elective cataract surgery. Aqueous humor samples of at least 50 μL were drawn from the anterior chamber at the beginning of the cataract operation. The concentrations of the fluoroquinolones in the anterior chambers were measured using high-performance liquid chromatography. To exclude a dilution effect of the anterior chamber (AC), they were related to the AC volumes (measured by 3-dimensional modeling of central Orbscan [Bausch & Lomb] slit-image photos) and AC depths (measured by ultrasound). Results The mean concentration of levofloxacin (1139.9 ng/mL ± 717.1 [SD]) in the aqueous humor was significantly higher (P = .0008) than that of ofloxacin (621.7 ± 368.7 ng/mL). The aqueous humor concentrations correlated negatively with the measured volumes and depths of the ACs. Conclusions The new fluoroquinolone, levofloxacin, is more soluble in water enabling the use of higher drug concentrations (0.5%) compared with other currently available fluoroquinolone eyedrops (0.3%). The concentration AC with levofloxacin eyedrops was about 2-fold that reached with ofloxacin eyedrops. The concentration of the antibacterial isomer was approximately 3.5 to 4 times higher when levofloxacin was administered, assuming negligible stereoselective uptake. |
| Databáze: | OpenAIRE |
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