Hemogen is a novel nuclear factor specifically expressed in mouse hematopoietic development and its human homologue EDAG maps to chromosome 9q22, a region containing breakpoints of hematological neoplasms
| Autor: | Li V. Yang, Anne Galy, Rhonda H. Nicholson, Li Li, Joseph Kaplan |
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| Rok vydání: | 2001 |
| Předmět: |
Embryology
Molecular Sequence Data Down-Regulation Biology Mice Bone Marrow Gene expression medicine Animals Humans Tissue Distribution Blood islands Amino Acid Sequence Nuclear protein Cloning Molecular In Situ Hybridization Cell Nucleus Base Sequence Sequence Homology Amino Acid Reverse Transcriptase Polymerase Chain Reaction Hematopoietic Tissue Nuclear Proteins medicine.disease Blotting Northern Hematopoietic Stem Cells Molecular biology Leukemia Haematopoiesis medicine.anatomical_structure Liver Hematologic Neoplasms COS Cells Bone marrow Stem cell Chromosomes Human Pair 9 Spleen Plasmids Developmental Biology |
| Zdroj: | Mechanisms of Development. 104(1-2):105-111 |
| ISSN: | 0925-4773 |
| DOI: | 10.1016/s0925-4773(01)00376-8 |
| Popis: | We cloned a novel murine gene, designated Hemogen (hemopoietic gene), which was sequentially expressed in active hematopoietic sites and downregulated in the process of blood cell differentiation. Hemogen transcripts were specifically detected in blood islands, primitive blood cells and fetal liver during embryogenesis, and then remained in bone marrow and spleen in adult mice. Immunostaining demonstrated that Hemogen was a nuclear protein. We also identified a human homologue of Hemogen, named EDAG, which was mapped to chromosome 9q22, a leukemia breakpoint. Like Hemogen, EDAG exhibited specific expression in hematopoietic tissues and cells. Taken together, these data are consistent with Hemogen and EDAG playing an important role in hematopoietic development and neoplasms. |
| Databáze: | OpenAIRE |
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