A computer aided system for systematic production and revision of sequence patterns

Autor: Jean Sallantin, H. Ripoche
Rok vydání: 1996
Předmět:
Zdroj: Biochimie. 78:370-375
ISSN: 0300-9084
DOI: 10.1016/0300-9084(96)84769-9
Popis: We used two complementary fields, object-oriented databases and machine learning, to produce and revise a set of protein sequence patterns. In a first stage, we show that object-oriented query languages are well suited for the production of patterns as well as for the interpretation of the biological function of new (uncharacterized) sequences. In a second stage, a classification is built from the set of sequences according to the pattern matches. This classification may be criticized by a specific analysis method, which yields back to revise sequences and patterns. In our application, we have used concept lattices as a classification method and sequence multiple alignment for criticism.
Databáze: OpenAIRE