The facile synthesis of copper oxide quantum dots on chitosan with assistance of phyto-angelica for enhancing the human osteoblast activity to the application of osteoporosis
| Autor: | Zhongqing Hu, Tang Yanghua, Xiong Zhenfei, Wenjie Zheng, Yue Zhenshuang |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Copper oxide
030303 biophysics Biophysics chemistry.chemical_element 02 engineering and technology Chitosan 03 medical and health sciences chemistry.chemical_compound Quantum Dots medicine Humans Radiology Nuclear Medicine and imaging MTT assay Cells Cultured Angelica Cell Proliferation Bone mineral 0303 health sciences Osteoblasts Radiation Radiological and Ultrasound Technology Plant Extracts Cell growth Spectrum Analysis technology industry and agriculture Osteoblast equipment and supplies 021001 nanoscience & nanotechnology Copper Solvent medicine.anatomical_structure chemistry Osteoporosis 0210 nano-technology Nuclear chemistry |
| Zdroj: | Journal of Photochemistry and Photobiology B: Biology. 191:6-12 |
| ISSN: | 1011-1344 |
| DOI: | 10.1016/j.jphotobiol.2018.11.009 |
| Popis: | Osteoblasts are an important key factor for the pathogenesis of several bone-related diseases, notably in osteoporosis. Osteoporosis is a disorder categorized based on the bone mineral density (BMD) and an alteration in the bone micro-architecture had been considered as the major determinant for increasing the fracture risk. The available medicine for curing the osteoporosis shows a minimal or no activity against the genesis or function of osteoblasts. The present study was conducted to determine the influence of phyto Angelica species (Ang.) mediated synthesized copper quantum dots decorated chitosan on human osteoblast cells for application of osteoporosis. The phyto compound of Angelica sp. was extracted by ethanol as solvent and it has been characterized through spectral analyses. An Angelica sp. mediated synthesized copper oxide quantum dots (CuO QDs) and the presence of CuO QDs on chitosan have been analyzed and exhibited by important spectral investigations. The morphological observation of CuO QDs on the chitosan (CS) was visualized by the microscopic analyses. The MTT assay results showed that cell growth of CuO QDs/CS-Ang. by the concentration dependent. The highest cell growth (87%) was noted at 5 μg/mL followed by 80 and 77% at 15 and 25 μg/mL respectively. The functional groups and potential compounds of Angelica sp. with CuO QDs/CS has been improved the osteoblast cell activity as prophylactic potentials against osteoporosis. |
| Databáze: | OpenAIRE |
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